Continuous positive airway pressure: early, late, or stay with synchronized intermittent mandatory ventilation?

Journal of Perinatology : Official Journal of the California Perinatal Association
E Bancalari, T del Moral

Abstract

Mechanical ventilation is associated with significant short- and long-term morbidity in small preterm infants. Continuous positive airway pressure applied through nasal prongs is an effective, less-invasive method to improve gas exchange and reduce apnea in these infants. A large number of studies have evaluated the possibility of reducing the need or duration of mechanical ventilation by early use of nasal continuous positive airway pressure shortly after birth and by applying it after extubation. Although results of these trials have not been consistent, most of the evidence suggests that nasal continuous positive airway pressure is a viable alternative to mechanical ventilation in many preterm infants and that its use after extubation contributes to maintain better lung function and reduces apnea. Despite this, there is no evidence that these beneficial short-term effects translate into lower rates of long-term morbidity such as bronchopulmonary dysplasia and neurologic sequelae or mortality rates.

Associated Clinical Trials

Jan 13, 2009·Jucille do Amaral Meneses, Jucille do Amaral Meneses

References

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May 7, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Vivek NarendranAlan H Jobe
Sep 3, 2004·Pediatrics·Neil N FinerUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
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Aug 1, 1999·Journal of Paediatrics and Child Health·P G Davis, D J Henderson-Smart

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Citations

Feb 25, 2010·European Journal of Pediatrics·J Peter de WinterLuc J I Zimmermann
Aug 19, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·V BhandariN L Brodsky
Jul 5, 2011·Paediatric Respiratory Reviews·Ramadan A MahmoudGerd Schmalisch
Nov 16, 2007·The Journal of Perinatal & Neonatal Nursing·Debbie Fraser Askin

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