Continuous positive airway pressure improves gait control in severe obstructive sleep apnoea: A prospective study

PloS One
Sébastien BaillieulSamuel Verges

Abstract

Severe obstructive sleep apnoea (OSA) can lead to neurocognitive alterations, including gait impairments. The beneficial effects of continuous positive airway pressure (CPAP) on improving excessive daytime sleepiness and daily functioning have been documented. However, a demonstration of CPAP treatment efficacy on gait control is still lacking. This study aims to test the hypothesis that CPAP improves gait control in severe OSA patients. In this prospective controlled study, twelve severe OSA patients (age = 57.2±8.9 years, body mass index = 27.4±3.1 kg·m-2, apnoea-hypopnoea index = 46.3±11.7 events·h-1) and 10 healthy matched subjects were included. Overground gait parameters were recorded at spontaneous speed and stride time variability, a clinical marker of gait control, was calculated. To assess the role of executive functions in gait and postural control, a dual-task paradigm was applied using a Stroop test as secondary cognitive task. All assessments were performed before and after 8 weeks of CPAP treatment. Before CPAP treatment, OSA patients had significantly larger stride time variability (3.1±1.1% vs 2.1±0.5%) and lower cognitive performances under dual task compared to controls. After CPAP treatment, stride time vari...Continue Reading

References

Jul 22, 2005·Journal of Neuroengineering and Rehabilitation·Jeffrey M Hausdorff
Feb 8, 2006·Journal of the American Geriatrics Society·Joe VergheseRichard B Lipton
Sep 20, 2006·Gait & Posture·Kimberlee JordanKarl M Newell
Dec 7, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Galit Yogev-SeligmannNir Giladi
Apr 11, 2008·Gait & Posture·Matthew A SchragerAnne Shumway-Cook
Nov 3, 2010·American Journal of Respiratory and Critical Care Medicine·Nicola CanessaLuigi Ferini-Strambi
Feb 11, 2012·Journal of Neuroengineering and Rehabilitation·Olivier BeauchetGilles Allali
Mar 16, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Galit Yogev-SeligmannNir Giladi
Aug 24, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Romola S BucksPeter Eastwood
Mar 6, 2013·The Journal of Nutrition, Health & Aging·O BeauchetC Annweiler
Apr 11, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·L Ferini-StrambiC Castronovo
Sep 3, 2013·American Journal of Respiratory and Critical Care Medicine·Richard J SchwabUNKNOWN ATS Subcommittee on CPAP Adherence Tracking Systems
May 3, 2014·Journal of Neurophysiology·Bradford L RankinJesse C Dean
Jul 8, 2014·Respiratory Physiology & Neurobiology·G AllaliF Assal
Aug 22, 2014·Sleep·Vincenza CastronovoAndrea Falini
Aug 26, 2014·BMC Pulmonary Medicine·Sébastien CelleOlivier Beauchet
Apr 19, 2015·The Lancet. Respiratory Medicine·Ivana RosenzweigMary J Morrell
Jun 16, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Esther I SchwarzMalcolm Kohler
Feb 20, 2016·Thorax·Francis DegacheRaphaël Heinzer
May 4, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nancy A Kerner, Steven P Roose
Jan 1, 2015·Nature Reviews. Disease Primers·Patrick LévyJean-Louis Pépin

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Citations

Jun 26, 2018·Current Neurology and Neuroscience Reports·Antonio Culebras, Sanam Anwar
Mar 19, 2020·European Journal of Applied Physiology·Louis ClavelBaptiste Sandoz

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Clinical Trials Mentioned

NCT02854280

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
OptoGait
Posturewin

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