Abstract
Recent studies report a link between obstructive sleep apnea (OSA) syndrome, low vitamin D levels, and high parathyroid hormone (PTH) concentrations. The aim of the current study is to evaluate the effect of 7-night continuous positive airway pressure (CPAP) therapy on serum vitamin D, PTH, and calcium levels in patients with severe OSA syndrome. Patients with severe OSA were enrolled into the study and compared to control subjects. Patients with OSA underwent CPAP therapy for 7 nights and were consequently divided into responders (OSA-R, mean residual AHI < 5/h) and nonresponders (OSA-nR, mean residual AHI > 5/h). Serum vitamin D, PTH, and calcium levels were measured at baseline in patients with severe OSA (apnea-hypopnea index > 30/h) and control subjects. Patients with OSA underwent a final morning blood sample after 7-night CPAP therapy. We enrolled 90 patients with OSA into the study (65 OSA-R and 25 OSA-nR) compared to 32 control subjects. At baseline, lower vitamin D and higher PTH levels were detected in the OSA group compared to controls. After 7-night CPAP therapy, male OSA-R patients showed a significant increase in vitamin D levels. Conversely, female OSA-R patients did not show the same increase in vitamin D level...Continue Reading
Citations
Nov 3, 2016·American Journal of Epidemiology·Priscila F TempakuSergio Tufik
Mar 21, 2017·Journal of Sleep Research·Alessandro MicarelliMarco Alessandrini
Mar 23, 2017·Sleep·Claudio LiguoriFabio Placidi
Jul 8, 2017·PloS One·Ronaldo D PiovezanDalva Poyares
Mar 5, 2020·PloS One·Xiaoying LiuKaye E Brock
Aug 18, 2018·Journal of Diabetes Research·Hong ShenGuangdong Sun
Jul 17, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Baha Al-ShawwaDavid G Ingram
Jul 11, 2020·Sleep & Breathing = Schlaf & Atmung·Izolde BouloukakiSophia Schiza
Aug 3, 2020·Sleep & Breathing = Schlaf & Atmung·Dimitra I SiachpazidouKonstantinos I Gourgoulianis
Apr 2, 2019·JDR Clinical and Translational Research·H EimarC Flores-Mir
May 17, 2019·Rejuvenation Research·Judit PákóAndrás Bikov
Sep 29, 2020·Curēus·Philip C NwabuforSamson O Oyibo
Jun 21, 2018·BMC Pediatrics·Ji-Hyeon ShinHojong Kim
Nov 11, 2020·Respiratory Research·Xiaoyan LiJie Yun
Nov 3, 2020·Food Science & Nutrition·Shoumeng YanWeiwei Cui
Aug 12, 2021·Scientific Reports·Adam Domonkos TarnokiAndras Bikov
Nov 9, 2021·Expert Review of Molecular Diagnostics·Sartaj KhuranaSudeep Bose