Continuous positive-pressure ventilation decreases right and left ventricular end-diastolic volumes in the dog

Circulation Research
J E FewellE Rapaport

Abstract

We investigated the mechanism(s) responsible for the decreased cardiac output during continuous positive-pressure ventilation (CPPV). Seven dogs were anesthetized with chloralose-urethane, intubated, and ventilated using a volume ventilator. We measured heart rate, stroke volume, and the determinants of stroke volume: left and right ventricular end-diastolic volumes, isovolumic and ejection phase indices of myocardial contractility, and pulmonary and systemic arterial pressures. Myocardial blood flow was estimated using radioactive microspheres. Variables were measured during a control period of intermittent positive-pressure ventilation (IPPV), 8-20 minutes after the initiation of CPPV using 12 cm H2O positive end-expiratory pressure (PEEP), and 8-20 minutes after the removal of PEEP. CPPV decreased cardiac output but did not affect total or regional myocardial blood flow or the ratio of subendocardial to subepicardial blood flow. Isovolumic and ejection phase indices of myocardial cointractility, heart rate, and systemic arterial pressure did not change during CPPV. Right and left ventricular end-diastolic and end-systolic volumes decreased markedly during CPPV. We conclude that CPPV decreases cardiac output in accordance wit...Continue Reading

References

May 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S S CassidyR L Johnson
Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Mar 11, 1975·Critical Care Medicine·S R Powers, R E Dutton
May 1, 1974·Cardiovascular Research·D M DavidsonJ Ross
Mar 1, 1972·Journal of Applied Physiology·J Keroes, E Rapaport
Sep 1, 1972·The Journal of Clinical Investigation·K J FalkeM B Laver
May 1, 1973·Journal of Applied Physiology·H J Tucker, J F Murray
Aug 1, 1973·Journal of Applied Physiology·R L Jones, E G King
Nov 1, 1969·Canadian Anaesthetists' Society Journal·R W McIntyreP R Ramachandran
Nov 1, 1969·The American Journal of Physiology·K WildenthalJ H Mitchell
Mar 1, 1969·The Journal of Clinical Investigation·G GlickS E Epstein
Sep 1, 1969·The American Journal of Physiology·K WildenthalJ H Mitchell
Jul 1, 1961·The American Journal of Physiology·C E CROSSP F SALISBURY
Jul 1, 1961·The American Journal of Physiology·L L HEFNERT J REEVES
Jul 1, 1963·The American Journal of Physiology·A G WALLACEJ H MITCHELL
Jun 1, 1964·The Journal of Clinical Investigation·R GORLINW C ELLIOTT
Mar 1, 1962·The American Journal of Physiology·R L MAULSBY, H E HOFF
Jan 1, 1948·The American Journal of Physiology·A COURNAND, H L MOTLEY
Feb 1, 1947·The American Journal of Physiology·J M BROOKHART, T E BOYD

❮ Previous
Next ❯

Citations

Jan 1, 1990·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·W SchneiderG Raberger
Oct 1, 1987·Pflügers Archiv : European journal of physiology·Y L HoogeveenW G Zijlstra
Jan 1, 1987·Annals of Biomedical Engineering·R Beyar, Y Goldstein
Jan 1, 1991·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·H F WeiX Y Ba
Sep 1, 1986·Canadian Anaesthetists' Society Journal·F A BurrowsD J Bohn
Aug 18, 2004·Sleep Medicine Reviews·M T Naughton
Feb 12, 1981·The New England Journal of Medicine·F JardinJ P Bourdarias
Oct 29, 2004·Critical Care Medicine·Tom P Aufderheide, Keith G Lurie
Jun 9, 2005·Critical Care Medicine·Jan Willem KuiperFrans B Plötz
Feb 18, 2006·Critical Care Medicine·Daniel P DavisDavid B Hoyt
Jun 19, 2003·The Journal of Trauma·Paul E PepeJane G Wigginton
Dec 17, 2009·The Journal of Trauma·David P MackieChrista Boer
Jun 1, 1995·Journal of Sleep Research·P C Deegan, W T McNicholas
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·A Versprille
Feb 1, 1994·Acta Anaesthesiologica Scandinavica·O J VeddengO A Smiseth
Feb 22, 2008·Journal of Veterinary Internal Medicine·S J Plunkett, M McMichael
Aug 8, 1981·British Medical Journal
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·S MehtaT Douglas Bradley
Dec 15, 2004·Der Anaesthesist·W G VoelckelK H Lindner
Jan 1, 1991·Intensive Care Medicine·F Jardin, J P Bourdarias
Aug 1, 1994·Intensive Care Medicine·J N ShephardT W Evans
May 1, 1987·The American Journal of the Medical Sciences·L L Schulman, Y Enson
Nov 1, 1992·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·H W MeijburgE O Robles de Medina
Sep 22, 1998·Chest·C A ManthousJ B Hall
Nov 24, 2011·Emergency Medicine Clinics of North America·Jose V NableChristopher T Stephens
Sep 18, 2007·Resuscitation·Daniel P Davis

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Next ❯

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