PMID: 11343920May 10, 2001Paper

Continuous recycling: a mechanism for modulatory signal transduction

Trends in Biochemical Sciences
B C Freeman, K R Yamamoto

Abstract

Modulatory signal transduction commonly requires efficient "on demand" assembly of specific multicomponent cellular machines that convert signals to cellular actions. This article suggests that for these signaling machines to detect and respond to fluctuations in signal strength, they must be continuously disassembled in an energy-dependent process that probably involves molecular chaperones.

References

Dec 19, 1979·Biochimica Et Biophysica Acta·G M Ringold
May 1, 1975·The Journal of Clinical Endocrinology and Metabolism·G Brandenberger, M Follenius
Nov 1, 1986·Endocrinology·A M Nardulli, B S Katzenellenbogen
Jan 1, 1985·Annual Review of Genetics·K R Yamamoto
Mar 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·J D Baxter, G M Tomkins
Dec 14, 1995·Nature·R L WagnerR J Fletterick
Jan 1, 1994·Annual Review of Biochemistry·M J Tsai, B W O'Malley
Dec 1, 1995·Molecular Biology of the Cell·S J Holley, K R Yamamoto
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Jun 10, 1998·Nature·S P Williams, P B Sigler
Jun 26, 1998·Current Opinion in Cell Biology·D Moras, H Gronemeyer
Nov 10, 1998·Genes & Development·B D DarimontK R Yamamoto
Jan 9, 1999·The Journal of Biological Chemistry·R J HachéY A Lefebvre
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·K I KangM G Catelli
Jul 8, 1999·Current Opinion in Cell Biology·A M Krecic, M S Swanson
Jan 5, 2000·Cell·S Nakielny, G Dreyfuss
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·C A LangeK B Horwitz
Jun 29, 2000·Annual Review of Biochemistry·R V WeathermanT S Scanlan
Nov 21, 2000·Trends in Biochemical Sciences·L L Kisselev, R H Buckingham

❮ Previous
Next ❯

Citations

May 10, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B Haendler
Mar 15, 2002·Current Opinion in Genetics & Development·Gordon L HagerMatthias Becker
Sep 3, 2009·Nature Cell Biology·Béatrice Desvergne, Christophe Héligon
Jun 16, 2009·Nature Structural & Molecular Biology·Diane C DeZwaanBrian C Freeman
Mar 9, 2004·Molecular Biology of the Cell·Neal D Freedman, Keith R Yamamoto
Oct 24, 2007·Molecular and Cellular Biology·Oyetunji A ToogunBrian C Freeman
Oct 1, 2004·Molecular and Cellular Biology·Linda B Lingelbach, Kenneth B Kaplan
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Hélène PrigentDjillali Annane
Oct 17, 2006·PLoS Computational Biology·Mariko IzumoCarl Hirschie Johnson
Nov 25, 2003·Cell Stress & Chaperones·Sara J Felts, David O Toft
Feb 21, 2014·Molecular Biology of the Cell·Ioannis KasioulisPatricia L Yeyati
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·I SwameyeU Klingmuller
Dec 23, 2009·Progress in Biophysics and Molecular Biology·Denis Michel
May 15, 2009·Journal of Cellular and Molecular Medicine·Arun K MankanRoss McManus
Dec 14, 2006·International Journal of Cancer. Journal International Du Cancer·Renée ChmelarNorman M Greenberg
Feb 18, 2015·Journal of Molecular Biology·Elena Zelin, Brian C Freeman
Sep 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·F ChenL Freedman
May 26, 2004·Cellular Signalling·William B PrattDonald B DeFranco
Aug 29, 2006·Biochemical Pharmacology·Wim Vanden BergheGuy Haegeman
Jun 30, 2006·Trends in Endocrinology and Metabolism : TEM·Didier Picard
Aug 30, 2011·Molecular and Cellular Endocrinology·Becky L Conway-CampbellStafford L Lightman
Dec 17, 2009·Biochimica Et Biophysica Acta·Pablo C Echeverria, Didier Picard
Oct 6, 2007·Critical Reviews in Biochemistry and Molecular Biology·Suzannah RutherfordBillie J Swalla
Jun 29, 2002·Molecular Endocrinology·Donald B DeFranco
Feb 13, 2019·Cold Spring Harbor Perspectives in Biology·Zlata GvozdenovBrian C Freeman
Oct 30, 2001·The Journal of Biological Chemistry·Shilpa PanditAyesha Sitlani
Oct 11, 2003·Molecular Endocrinology·Varykina G ThackraySteven K Nordeen
May 20, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hong HaoDavid H Ingbar
Sep 27, 2002·The Journal of Biological Chemistry·William P SullivanDavid O Toft

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.