Continuous Renal Replacement Therapy in Pediatric Severe Sepsis: A Propensity Score-Matched Prospective Multicenter Cohort Study in the PICU

Critical Care Medicine
Huijie MiaoYucai Zhang

Abstract

Continuous renal replacement therapy becomes available utilization for pediatric critically ill, but the impact of mortality rate in severe sepsis remains no consistent conclusion. The aim of the study is to assess the effect of continuous renal replacement therapy in pediatric patients with severe sepsis and the impact this therapy may have on their mortality. Propensity score-matched cohort study analyzing data prospectively collected by the PICUs over 2 years (2016-2018). Four PICUs of tertiary university children's hospital in China. The consecutive patients with severe sepsis admitted to study PICUs were enrolled from July 2016 to June 2018. The patients were divided into the continuous renal replacement therapy group and the conventional (noncontinuous renal replacement therapy) group. A total of 324 patients with severe sepsis were enrolled. The hospital mortality rate was 35.6% (64/180) in the continuous renal replacement therapy group and 47.9% (69/144) in the noncontinuous renal replacement therapy group. After propensity score adjustment, the hospital mortality rate was 21.3% (29/136) in the continuous renal replacement therapy group and 32.4% (44/136) in the noncontinuous renal replacement therapy group. In subgroup...Continue Reading

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Citations

May 15, 2020·Frontiers of Medicine·Yong LiUNKNOWN Multidisciplinary Team for COVID-19
Jun 22, 2021·Critical Care Explorations·Ran LiuRaimond L Winslow
May 10, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·ZhiJiang ChenQiyi Zeng

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Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

SPSS

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