Continuous stacking computational approach based automated microscope slide scanner

The Review of Scientific Instruments
Swetha MuraliSai Siva Gorthi

Abstract

Cost-effective and automated acquisition of whole slide images is a bottleneck for wide-scale deployment of digital pathology. In this article, a computation augmented approach for the development of an automated microscope slide scanner is presented. The realization of a prototype device built using inexpensive off-the-shelf optical components and motors is detailed. The applicability of the developed prototype to clinical diagnostic testing is demonstrated by generating good quality digital images of malaria-infected blood smears. Further, the acquired slide images have been processed to identify and count the number of malaria-infected red blood cells and thereby perform quantitative parasitemia level estimation. The presented prototype would enable cost-effective deployment of slide-based cyto-diagnostic testing in endemic areas.

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Citations

May 8, 2021·Journal of Biophotonics·Prasobhkumar P PSai Siva Gorthi
Jul 14, 2021·Journal of Microscopy·Prateek Katare, Sai Siva Gorthi

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