Continuous stimulation of transected distal nerves fails to prolong action potential propagation

Clinical Orthopaedics and Related Research
Tadhg O'GaraMark Stewart

Abstract

Wallerian degeneration of the distal portion of a cut nerve is considered irreversible. A possible reason for degeneration is lack of axon stimulation in the distal, cut nerves. We hypothesized greater rates of stimulation of distal nerve stumps would prolong time to action potential propagation failure, and uncut nerves would not be damaged by implanted nerve stimulators. We also hypothesized that action potentials measured from the body of the sciatic nerve would show similar response as motor-evoked potentials measured in the muscles innervated by branches of the sciatic nerve. We implanted a nerve stimulator onto distal cut sciatic nerves of rats and recorded motor-evoked potentials. Three groups were stimulated at 1 Hz (once per second), 0.1 Hz (once per 10 seconds), and 0.01 Hz (once per 100 seconds) respectively. Motor-evoked potentials progressively declined after nerve transection, failing faster at 1 Hz (26.8 hours +/- 108 minutes) and 0.1 Hz (22 hours +/- 66 minutes) compared with stimulation at 0.01 Hz (36.75 hours +/- 83 minutes). Intact axons were not damaged by implanted nerve stimulators. Action potentials recorded directly from nerves were equivalent to motor- evoked potentials. Failure of motor-evoked potentia...Continue Reading

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Citations

Mar 25, 2011·British Medical Bulletin·Pilar Martínez de AlbornozNicola Maffulli
Jan 25, 2013·Journal of Korean Neurosurgical Society·Chang-Hyun LeeKi-Jeong Kim
Aug 16, 2012·The Journal of Physiological Sciences : JPS·Isaac NaggarMark Stewart
Jul 16, 2014·Journal of Molecular Neuroscience : MN·Ningxi ZhuShiting Li
Oct 27, 2020·Frontiers in Bioengineering and Biotechnology·Shaochen SongRui Li

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