PMID: 6112654May 1, 1981Paper

Continuous subcutaneous insulin infusion: comparison of plasma insulin profiles after infusion or bolus injection of the mealtime dose

Metabolism: Clinical and Experimental
P D HomeC Binder

Abstract

To help optimize meal-time blood glucose control in diabetic patients by continuous subcutaneous insulin infusion we have studied plasma insulin profiles in six normal subjects, suppressing endogenous insulin secretion with somatostatin. Insulin was administered subcutaneously either as a bolus or by high-rate infusion. Mean infusion profiles were similar on the two occasions, with peak levels at 75 and 90 min respectively, and a linear decline to 34% and 36% of peak concentrations at 5 h. Bolus injection resulted in a faster rise in insulin concentration, more consistent with physiological requirements. It is concluded that bolus delivery would be similar in effect while mechanically simpler to achieve than infusion, when part of a dual rate subcutaneous infusion system. The dose should be given 30 min before meals, if peak insulin concentrations are to be coincident with those found physiologically. Insulin concentrations remain high in the post-absorptive phase.

Associated Clinical Trials

Apr 22, 2015·Ibragimova Lyudmila, Ibragimova Lyudmila

References

Jan 28, 1978·British Medical Journal·J C PickupK G Alberti
Nov 1, 1979·Diabetologia·T LauritzenC Binder
Jan 1, 1978·Diabetes·O K FaberA H Rubenstein
Jan 12, 1978·The New England Journal of Medicine·V A Koivisto, P Felig
Dec 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J E GerichP H Forsham
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Aug 1, 1971·The Journal of Clinical Endocrinology and Metabolism·R C TurnerJ D Nabarro
Jul 1, 1960·The Journal of Clinical Investigation·R S YALOW, S A BERSON

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Citations

Jan 1, 1985·Diabetologia·K FalholtL G Heding
Sep 1, 1984·Medical & Biological Engineering & Computing·J C Pickup, D Rothwell
Apr 30, 1999·Diabetes Research and Clinical Practice·H Overmann, L Heinemann
Jun 6, 2000·Advanced Drug Delivery Reviews·J Brange, A Vølund
Jul 17, 1997·The New England Journal of Medicine·F Holleman, J B Hoekstra
Jan 5, 2005·Diabetes Technology & Therapeutics·Lutz Heinemann, James H Anderson
Jun 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·P O OlssonJ Asplund
May 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·L Heinemann
Jul 1, 1983·Journal of Biomedical Engineering·D RothwellJ A Parsons
Aug 30, 2008·The Mount Sinai Journal of Medicine, New York·Jennifer Sherr, William V Tamborlane
Oct 1, 1986·Engineering in Medicine·J C Pickup
Nov 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·S M Furler, E W Kraegen
Jul 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·P Hildebrandt, K Birch
Mar 1, 2012·Nature Reviews. Endocrinology·John C Pickup
Apr 18, 1981·British Medical Journal·D R OwensR G Newcombe
Oct 1, 1994·Postgraduate Medical Journal·S R Page, R B Tattersall
May 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·J C Pickup

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