Continuous Thermodilution Method to Assess Coronary Flow Reserve.

The American Journal of Cardiology
Alejandro Gutiérrez-BarriosFernando Alfonso

Abstract

Coronary flow reserve (CFR) is a well-validated flow-based physiological parameter that has shown value in clinical risk stratification. CFR can be invasively assessed, classically by Doppler and, more recently, by thermodilution with saline boluses (CFRthermo-bolus). Alternatively, continuous thermodilution is a novel operator-independent, highly-reproducible technique to invasively quantify maximum absolute coronary flow (AF). This study aimed to assess the feasibility of this method to quantify resting AF and to determine CFR (CFRThermo-infusion) as compared with CFRthermo-bolus. Sixty-two consecutive patients with suspicion of coronary disease and absence of significant epicardial lesions were prospectively investigated. AF at maximal hyperemia (20 mL/min) and at lower infusion rates (6-8-10-12 mL/min) were systematically measured using a dedicated catheter and a temperature/pressure guidewire. The absence of baseline Pd/Pa decrease at 6 (0.15 ± 0.2%), 8 (0.17 ± 0.18%) and 10 mL/min (0.2 ± 0.12%) demonstrated absence of hyperemia at ≤10 mL/min (all p = NS). However, at 12 mL/min hyperemia was confirmed by a significant decrease in Pd/Pa (1.3 ± 1.5%, p <0.01) and increase in AF from 10 mL/min to 12 mL/min (31.4 ± 28.1 mL, p ...Continue Reading

References

Feb 1, 1972·The American Journal of Cardiology·W Ganz, H J Swan
Oct 24, 2001·Circulation·B De BruyneG R Heyndrickx
May 30, 2002·Circulation·Nico H J PijlsFrans Van De Vosse
Jun 25, 2003·Circulation·William F FearonAlan C Yeung
Feb 20, 2004·European Heart Journal·Emanuele BarbatoUNKNOWN Week 25 study group
Dec 11, 2007·Journal of the American College of Cardiology·Wilbert AarnoudseFrans van de Vosse
Feb 25, 2009·Medical Engineering & Physics·Marcel van't VeerFrans N van de Vosse
Aug 1, 2013·Circulation. Cardiovascular Interventions·Tim P van de HoefMartijn Meuwissen
Feb 26, 2016·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Inge WijnbergenNico H J Pijls
Mar 12, 2016·Journal of the American College of Cardiology·Joo Myung LeeBon-Kwon Koo
Aug 21, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marcel van 't VeerBernard De Bruyne
Mar 28, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marcos Garcia-GuimaraesFernando Alfonso
Apr 13, 2017·Circulation. Cardiovascular Interventions·Bernard De BruyneNico H J Pijls
May 24, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Johan SvanerudZiad A Ali
Jun 6, 2018·Circulation. Cardiovascular Interventions·Panagiotis XaplanterisBernard De Bruyne

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