Continuous theta burst stimulation over the left dorsolateral prefrontal cortex decreases medium load working memory performance in healthy humans

PloS One
Nathalie SchicktanzKyrill Schwegler

Abstract

The dorsolateral prefrontal cortex (DLPFC) plays a key role in working memory. Evidence indicates that transcranial magnetic stimulation (TMS) over the DLPFC can interfere with working memory performance. Here we investigated for how long continuous theta-burst stimulation (cTBS) over the DLPFC decreases working memory performance and whether the effect of cTBS on performance depends on working memory load. Forty healthy young subjects received either cTBS over the left DLPFC or sham stimulation before performing a 2-, and 3-back working memory letter task. An additional 0-back condition served as a non-memory-related control, measuring general attention. cTBS over the left DLPFC significantly impaired 2-back working memory performance for about 15 min, whereas 3-back and 0-back performances were not significantly affected. Our results indicate that the effect of left DLPFC cTBS on working memory performance lasts for roughly 15 min and depends on working memory load.

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Citations

Oct 27, 2018·The European Journal of Neuroscience·Bernardo Villa-SánchezMirta Fiorio
Feb 6, 2020·Journal of Cognitive Neuroscience·Eva LoosDominique J-F de Quervain
Aug 29, 2018·Scientific Reports·Paolo CapotostoAlfredo Brancucci
Sep 5, 2017·Frontiers in Neuroscience·Raquel Viejo-SoberaElena M Marron
Aug 15, 2018·Journal of Integrative Neuroscience·Chia-Yen Yang, Chong-Kai Huang
Dec 8, 2017·Translational Psychiatry·Nicholas L BalderstonChristian Grillon
May 15, 2021·Current Biology : CB·Veith WeilnhammerPhilipp Sterzer

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