Continuous theta-burst stimulation over the dorsal premotor cortex interferes with associative learning during object lifting

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Dennis A NowakCarlos Schönfeldt-Lecuona

Abstract

When lifting objects of different mass, humans scale grip force according to the expected mass. In this context, humans are able to associate a sensory cue, such as a colour, to a particular mass of an object and link this association to the grip forces necessary for lifting. Here, we study the role of the dorsal premotor cortex (PMd) in setting-up an association between a colour cue and a particular mass to be lifted. Healthy right-handed subjects used a precision grip between the index finger and thumb to lift two different masses. Colour cues provided information about which of the two masses subjects would have to lift. Subjects first performed a series of lifts with the right hand to establish a stable association between a colour cue and a mass, followed by 20sec of continuous high frequency repetitive trancranial magnetic stimulation using a recently developed protocol (continuous theta-burst stimulation, cTBS) over (i) the left primary motor cortex, (ii) the left PMd and (iii) the left occipital cortex to be commenced by another series of lifts with either the right or left hand. cTBS over the PMd, but not over the primary motor cortex or O1, disrupted the predictive scaling of isometric finger forces based on colour cu...Continue Reading

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Citations

Jun 10, 2010·Experimental Brain Research·Scott T Grafton
May 25, 2011·Experimental Brain Research·Diana J Gorbet, W Richard Staines
Mar 17, 2009·Brain Topography·Lizbeth Cárdenas-MoralesCarlos Schönfeldt-Lecuona
Apr 6, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jennifer A Foley, Sergio Della Sala
May 6, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Laura Valkonen, Joanna Brooks
Dec 17, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marco TaubertDennis A Nowak
Feb 9, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jennifer A Foley, Sergio Della Sala
Jan 19, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jennifer A Foley, Sergio Della Sala
Jun 12, 2018·The Journal of Physiology·Ying-Zu HuangChin-Song Lu
Dec 5, 2014·Journal of Insect Science·Ricardo SalvadorEsteban Hopp
Nov 11, 2016·Journal of Neurophysiology·Pranav J Parikh, Marco Santello

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