Continuous theta burst stimulation over the supplementary motor area in refractory obsessive-compulsive disorder treatment: A randomized sham-controlled trial

Brain Stimulation
G Harika-GermaneauN Jaafari

Abstract

Obsessive-compulsive disorder (OCD) is a complex disorder with 40 to 60 % of patients resistant to treatment. Theta burst transcranial magnetic stimulation (TBS) is a promising new technique that has been shown to induce potent and long lasting effects on cortical excitability. The present study evaluated for the first time therapeutic efficacy and tolerability of continuous TBS (cTBS) over the supplementary motor area (SMA) in treatment resistant OCD patients using a double blind, sham-controlled design. Thirty treatment resistant OCD outpatients were randomized to receive either active cTBS or sham cTBS for 6 weeks (5 sessions per week). Each treatment session consisted of 600 stimuli at an intensity of 70% of resting motor threshold. Patients were evaluated at baseline, at the end of treatment (week 6), and follow-up (week 12). Response to treatment was defined as at least 25% decrease on the Yale-Brown Obsessive Compulsive Scale. There was no significant difference between active and sham cTBS groups in treatment efficacy. Responder rates were not different between the two groups at week 6 (cTBS 28% versus sham 36%; p = 0.686) and week 12 (cTBS 28% versus sham 36%; p = 0.686). Depressive and anxious symptoms improvements we...Continue Reading

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Citations

Jul 21, 2020·Expert Review of Neurotherapeutics·Alexis G McCathernEric A Storch
Jan 23, 2021·Neuroscience and Biobehavioral Reviews·Stephanie HomanPhilipp Homan
Mar 30, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·M Prabhavi N PereraPaul B Fitzgerald
Jun 6, 2021·International Journal of Computer Assisted Radiology and Surgery·John S H BaxterPierre Jannin

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