PMID: 7026979Aug 1, 1981Paper

Continuous treatment with natural oestrogens and progestogens. A method to avoid endometrial stimulation

Maturitas
B Staland

Abstract

Treatment of menopausal symptoms with a combination of natural oestrogens (17beta-oestradiol and oestriol) and a gestagen (norethisterone acetate), given continuously without interruption, has been found to have a good effect on menopausal symptoms, at the same time as the endometrium is maintained or brought to an atrophic state. This method seems to be a new approach to oestrogenic therapy, and in spite of the inconvenience of rather frequent--though as a rule very slight--bleeding during the first months of treatment, it should be of value. After 3-4 mth of treatment bleeding practically never occurs and the endometrium almost invariably becomes completely atrophic. It would seem that this might imply a lowered risk of development of endometrial cancer. A series of 265 patients treated in accordance with this principle for up to more and than 4 yr is presented.

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Citations

Sep 1, 1995·Journal of Clinical Pharmacology·R Sagraves
Feb 1, 1995·American Journal of Obstetrics and Gynecology·S P SuhonenP Lähteenmäki
Sep 1, 1995·Maturitas·P Eiken, N Kolthoff
Jul 31, 1999·Fertility and Sterility·E Suvanto-Luukkonen, A Kauppila
Apr 10, 2003·Obstetrics and Gynecology·Leslie Miller, James P Hughes
Dec 1, 1996·Obstetrics and Gynecology·C M GroverA E Washington
Feb 12, 2002·Maturitas·Pia Eiken, Niels Kolthoff
Jan 1, 1993·Baillière's Clinical Endocrinology and Metabolism·M S Marsh, M I Whitehead
Aug 1, 1995·The Journal of the American Association of Gynecologic Laparoscopists·D R Phillips
Jul 11, 2001·Journal of Women's Health & Gender-based Medicine·M M ReganS L Greenspan
Jun 28, 2011·Menopause : the Journal of the North American Menopause Society·David F Archer
Dec 1, 1990·British Journal of Obstetrics and Gynaecology·A T Leather, J W Studd
Sep 1, 1991·British Journal of Obstetrics and Gynaecology·R J HawthornD M Hart
Apr 1, 1993·British Journal of Obstetrics and Gynaecology·K F GangarR W Beard
Dec 16, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·D W SturdeeA J Bragg
May 29, 2001·Journal of Clinical Pathology·K M Feeley, M Wells
Aug 13, 2005·Climacteric : the Journal of the International Menopause Society·M L Nguyên-PascalP D Delmas
Jan 21, 2015·Climacteric : the Journal of the International Menopause Society·L-Å MattssonUNKNOWN Study Group
Jan 19, 2008·Climacteric : the Journal of the International Menopause Society·D W SturdeeUNKNOWN CHOICE Study Investigators
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Feb 12, 2011·Seminars in Diagnostic Pathology·W Glenn McCluggage
Sep 1, 1996·Baillière's Clinical Obstetrics and Gynaecology·M C Rees
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Jan 1, 1995·American Journal of Obstetrics and Gynecology·T H RaudaskoskiT J Laatikainen

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