Continuous versus pulsatile administration of rotigotine in 6-OHDA-lesioned rats: contralateral rotations and abnormal involuntary movements.

Journal of Neural Transmission
Werner J SchmidtDieter Scheller

Abstract

Sustained drug delivery providing continuous dopaminergic stimulation is thought to prevent or delay the induction of motor complications (dyskinesia) in Parkinson's disease, whereas pulsatile administration is supposed to promote them. This study investigated the inducibility of sensitization and abnormal involuntary movements (AIMs), comparing continuous and pulsatile administration of rotigotine with pulsatile administration of 3,4-dihydroxy-L-phenylalanine (L-DOPA) for reference. Rats were unilaterally lesioned with 6 hydroxydopamine (6-OHDA). For pulsatile administration, L-DOPA-methylester (10 mg/kg L-DOPA i.p.) or rotigotine (1 mg/kg i.p.) were administered once or twice daily. For continuous administration, a slow release formulation of rotigotine was injected s.c. at a dose of 1 mg/kg every 48 h (experiment I) or every 24 h (experiment II). Pulsatile administration of rotigotine and L-DOPA caused contraversive rotations increasing progressively upon each successive treatment. AIMs started to occur after the second administration of L-DOPA but hardly after pulsatile rotigotine. Continuous rotigotine increased rotations, which reached a plateau after the second administration. No AIMs were observed under continuous admin...Continue Reading

References

Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Feb 17, 1984·European Journal of Pharmacology·M Herrera-Marschitz, U Ungerstedt
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·W Poewe, G K Wenning
Oct 29, 2000·Trends in Neurosciences·J A ObesoJ G Nutt
Oct 29, 2000·Trends in Neurosciences·A M GraybielC Capper-Loup
Jul 3, 2002·Nature Reviews. Neuroscience·M Angela CenciTimothy Schallert
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Jan 11, 2003·Journal of Neurology·M GerlachJ Schwarz
Aug 30, 2003·Journal of Neural Transmission. Supplementum·E C HirschJ M Launay
Jan 14, 2004·Neurology·Fabrizio Stocchi, C Warren Olanow
Aug 17, 2005·The European Journal of Neuroscience·Gerlinde A MetzKarim Fouad
Oct 14, 2005·Journal of Neurology·Stanley Fahn, UNKNOWN Parkinson Study Group
Nov 5, 2005·CNS Drugs·Neil A ReynoldsStephanie E Easthope
Sep 9, 2006·European Journal of Pharmacology·Valerie Bertaina-AngladeDieter K A Scheller

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Citations

Dec 29, 2010·Journal of Neural Transmission·E GrünblattM Gerlach
Dec 11, 2013·CNS Drugs·Marina Senek, Dag Nyholm
Sep 21, 2013·European Journal of Drug Metabolism and Pharmacokinetics·Willi CawelloMarina Braun
Dec 10, 2013·Expert Opinion on Investigational Drugs·Fabio Blandini, Marie-Therese Armentero
Nov 21, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jingwei TianXiaolin Guan
Feb 11, 2012·Fundamental & Clinical Pharmacology·Santiago Perez-LloretOlivier Rascol
Apr 14, 2011·British Journal of Pharmacology·Susan Duty, Peter Jenner
Aug 26, 2014·Annals of the New York Academy of Sciences·Arturo BenitezMahnaz Asgharnejad
Mar 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Liang YeYouxin Li
May 26, 2016·Expert Opinion on Drug Metabolism & Toxicology·Luigi Ferini-StrambiAndrea Galbiati

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