Continuous-waveform constant-current isolated physiological stimulator.

The Review of Scientific Instruments
Mark R HolcombVeniamin Y Sidorov

Abstract

We have developed an isolated continuous-waveform constant-current physiological stimulator that is powered and controlled by universal serial bus (USB) interface. The stimulator is composed of a custom printed circuit board (PCB), 16-MHz MSP430F2618 microcontroller with two integrated 12-bit digital to analog converters (DAC0, DAC1), high-speed H-Bridge, voltage-controlled current source (VCCS), isolated USB communication and power circuitry, two isolated transistor-transistor logic (TTL) inputs, and a serial 16 × 2 character liquid crystal display. The stimulators are designed to produce current stimuli in the range of ±15 mA indefinitely using a 20V source and to be used in ex vivo cardiac experiments, but they are suitable for use in a wide variety of research or student experiments that require precision control of continuous waveforms or synchronization with external events. The device was designed with customization in mind and has features that allow it to be integrated into current and future experimental setups. Dual TTL inputs allow replacement by two or more traditional stimulators in common experimental configurations. The MSP430 software is written in C++ and compiled with IAR Embedded Workbench 5.20.2. A control ...Continue Reading

References

Jan 28, 1998·IEEE Transactions on Bio-medical Engineering·E A CheeverD T George
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R O Brasil, J H Leal-Cardoso
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Apr 1, 1953·Annals of Surgery·E J BEATTIEB BLADES
Nov 6, 2007·The Review of Scientific Instruments·David N MashburnJohn P Wikswo
Aug 19, 2008·American Journal of Physiology. Heart and Circulatory Physiology·M M MaleckarN A Trayanova
Jan 7, 2009·The Review of Scientific Instruments·Mark R HolcombJohn P Wikswo
Aug 7, 2009·Experimental Biology and Medicine·Mark R HolcombVeniamin Y Sidorov

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Citations

Jul 23, 2013·Biophysical Journal·Marcella C WoodsVeniamin Y Sidorov
Jan 27, 2015·Journal of Neuroscience Methods·Anton SheininIzhak Michaelevski
Oct 16, 2018··Henning PohlKasper Hornbæk

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Methods Mentioned

BETA
pull-down
fluorescence imaging
chips

Software Mentioned

Windows
MSP430

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