Continuous wound infiltration versus epidural analgesia for midline abdominal incisions - a randomized-controlled pilot trial (Painless-Pilot trial; DRKS Number: DRKS00008023)

PloS One
Rosa KlotzAndre L Mihaljevic

Abstract

To test the feasibility of a randomized controlled study design comparing epidural analgesia (EDA) with continuous wound infiltration (CWI) in respect to postoperative complications and mobility to design a future multicentre randomized controlled trial. CWI has been developed to address drawbacks of EDA. Previous studies have established the equivalent analgesic potential of CWI compared to EDA. This is a single centre, non-blinded pilot randomized controlled trial at a tertiary surgical centre. Patients undergoing elective non-colorectal surgery via a midline laparotomy were randomized to EDA or CWI. Endpoints included recruitment, feasibility of assessing postoperative mobility with a pedometer and morbidity. No primary endpoint was defined and all analyses were explorative. CWI with local anaesthetics (experimental group) vs. thoracic EDA (control). Of 846 patients screened within 14 months, 71 were randomized and 62 (31 per group) included in the intention-to-treat analysis. Mobility was assessed in 44 of 62 patients and revealed no differences within the first 3 postoperative days. Overall morbidity did not differ between the two groups (measured via the comprehensive complication index). Median pain scores at rest were c...Continue Reading

References

Apr 1, 1991·British Journal of Anaesthesia·T I IonescuJ Van Rossum
Oct 6, 2000·Anesthesiology·F M Perkins, H Kehlet
Jul 4, 2002·American Journal of Surgery·Henrik Kehlet, Douglas W Wilmore
Jan 14, 2009·British Journal of Anaesthesia·T M CookUNKNOWN Royal College of Anaesthetists Third National Audit Project
Sep 29, 2009·Lancet·Peter McCullochJan Vandenbroucke
Mar 26, 2010·Annals of Internal Medicine·Kenneth F SchulzUNKNOWN CONSORT Group
Aug 14, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Erica J RevieStephen J Wigmore
Nov 20, 2012·International Journal of Nursing Studies·Peter CraigMark Petticrew
Jun 4, 2013·Annals of Surgery·Ksenija SlankamenacPierre-Alain Clavien
Jun 26, 2013·British Journal of Anaesthesia·E J Bartley, R B Fillingim
Aug 24, 2013·Anesthesia and Analgesia·Franklin Dexter
Aug 20, 2014·Anesthesia and Analgesia·Fabian O KooijMarkus W Hollmann
Apr 16, 2017·International Journal of Colorectal Disease·Ksenija SlankamenacMatthias Turina
Jul 12, 2018·Current Opinion in Anaesthesiology·Raphael Weiss, Daniel M Pöpping
Aug 31, 2018·The Cochrane Database of Systematic Reviews·Jon H SalicathMichael H Bennett
Dec 28, 2018·Current Opinion in Anaesthesiology·Tim J P Batchelor, Olle Ljungqvist

❮ Previous
Next ❯

Citations

Jan 8, 2021·Langenbeck's Archives of Surgery·Dedrick Kok Hong ChanChristopher Hang Liang Keh
Nov 6, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ryan HowleNeel Desai

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA
PCAs

Software Mentioned

randomizer
PAINLESS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of Gynecology and Obstetrics
Andrea RosMichael Hüppe
International Journal of Sports Physiology and Performance
Shona L HalsonPaul B Laursen
European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie
Klarieke Bravenboer-MonsterRene Wijnen
© 2021 Meta ULC. All rights reserved