Continuously available ratio of SpO2 /FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19

Respiratory Research
Xiaofan LuFangrong Yan

Abstract

Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56-2.13). The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.

References

Sep 10, 2015·American Journal of Respiratory and Critical Care Medicine·Elisabeth D RivielloRobert A Fowler
Apr 9, 2020·American Journal of Respiratory and Critical Care Medicine·Yang WangJun Wang

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Citations

Sep 4, 2020·PloS One·Alejandro Rodríguez-MolineroUNKNOWN COVID-19 research group of CSAPG
Feb 16, 2021·The American Journal of Emergency Medicine·Pierre CatoireCédric Gil-Jardiné
Apr 14, 2021·JAMA Network Open·Francisco Martín-RodríguezAncor Sanz-García
May 1, 2021·The European Respiratory Journal·Rocco Francesco RinaldoStefano Centanni

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Methods Mentioned

BETA
blood draws

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nlme R
JM R

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