Continuously Cultured Tissue Cells and Viral Vaccines: Potential advantages may be realized and potential hazards obviated by careful planning and monitoring

Science
Committee on Tissue Culture Viruses and Vaccines

Abstract

1) Continuously cultured tissue cells afford numerous potential advantages for the propagation of viruses to be used in vaccines. 2) Because continuously cultured tissue cells sooner or later become capable of growing into neoplasms when transplanted into a suitable host, every possible precaution should be taken to ensure that viral vaccines grown in cell cultures are free from living cells and cell particles larger than 0.5 to 1.0 micron. 3) The radical abnormalities that occur in cell lines derived from neoplasms and those that develop sooner or later in cell lines derived from normal tissue cannot be ignored. However, no evidence has been recorded (i) that untoward consequences follow administration of cell-free preparations from such cultures to humans or (ii) that oncogenic or other viral activity is associated with the ability of cells of these lines to grow into neoplasms when transplanted into a suitable host. It seems very unlikely, nevertheless, that acceptance could be won at present for the general use of a live-virus vaccine prepared from a virus grown in cells showing evidences of malignancy. This conclusion is based more on psychological and public relations considerations than on the available scientific inform...Continue Reading

Citations

Jan 1, 1987·Experimental Gerontology·J A Witkowksi
Jun 19, 2001·Current Opinion in Biotechnology·A S Lubiniecki, J C Petricciani
Nov 27, 1995·Annals of the New York Academy of Sciences·M R Hilleman

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