Continuum modeling of a neuronal cell under blast loading.

Acta Biomaterialia
Antoine Jérusalem, Ming Dao

Abstract

Traumatic brain injuries have recently been put under the spotlight as one of the most important causes of accidental brain dysfunctions. Significant experimental and modeling efforts are thus underway to study the associated biological, mechanical and physical mechanisms. In the field of cell mechanics, progress is also being made at the experimental and modeling levels to better characterize many of the cell functions, including differentiation, growth, migration and death. The work presented here aims to bridge both efforts by proposing a continuum model of a neuronal cell submitted to blast loading. In this approach, the cytoplasm, nucleus and membrane (plus cortex) are differentiated in a representative cell geometry, and different suitable material constitutive models are chosen for each one. The material parameters are calibrated against published experimental work on cell nanoindentation at multiple rates. The final cell model is ultimately subjected to blast loading within a complete computational framework of fluid-structure interaction. The results are compared to the nanoindentation simulation, and the specific effects of the blast wave on the pressure and shear levels at the interfaces are identified. As a conclusi...Continue Reading

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Citations

Dec 18, 2013·Biomechanics and Modeling in Mechanobiology·Antoine JérusalemJosé M Peña
Aug 20, 2014·Medicinal Research Reviews·Murali M YallapuSubhash C Chauhan
Feb 27, 2015·Biomechanics and Modeling in Mechanobiology·Alain GorielyEllen Kuhl
Mar 31, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Silvia BuddayEllen Kuhl
Dec 19, 2016·Acta Biomaterialia·S BuddayG A Holzapfel
Sep 14, 2019·International Journal for Numerical Methods in Biomedical Engineering·Xiancheng Yu, Mazdak Ghajari
Mar 3, 2019·Scientific Reports·Toru TakahashiAkira Tsukamoto
May 20, 2020·Cellular and Molecular Bioengineering·Mohan Yasodharababu, Arun K Nair
Feb 23, 2020·Frontiers in Neurology·Annaclaudia MontaninoSvein Kleiven
Jul 24, 2015·Nanotechnology·Antonio BoccaccioCarmine Pappalettere
Jul 8, 2018·Scientific Reports·Daniel Garcia-GonzalezAntoine Jérusalem
Oct 12, 2019·Journal of the Mechanical Behavior of Biomedical Materials·Yun BingAntoine Jérusalem
Jun 29, 2017·Acta Biomaterialia·S BuddayE Kuhl
Apr 4, 2021·Materials·Elisa FicarellaLuciano Lamberti

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