Contraceptive devices: intravaginal and intrauterine delivery systems

Expert Review of Medical Devices
Giuseppe BenagianoManuela Farris

Abstract

Substances with an antifertility activity can be delivered directly into the vagina and the uterus. Indeed, it has been known for decades that the vaginal mucosa is an excellent way through which to deliver a number of compounds to the general circulation. Research and development efforts have concentrated on rings delivering only progestins, or both an estrogen and a progestin. The only combined ring marketed so far releases 15 microg ethynyl estradiol and 120 microg etonogestrel, and has a failure rate between one and two per 100 women-years of use. It has a preset duration of action of 1 month, has to be inserted before day 5 of the cycle, irrespective of the presence of menstrual flow, and withdrawn after 21 days, thereby allowing proper cycle control. Among rings releasing only a progestin, one device releasing progesterone has been marketed; all others are still under development. Unlike other long-term methods, vaginal rings do not require the involvement of a healthcare professional and can be inserted and removed by the user. The first attempt at achieving contraception by inserting a device in the uterus is 100 years old. Half a century later, medicated intrauterine systems were investigated; they are superior to iner...Continue Reading

References

Dec 10, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A Kessler, C C Standley
Dec 17, 1977·British Medical Journal·R Snowden
Jun 1, 1975·Journal of Steroid Biochemistry·L L DoyleR A Harrison
May 1, 1975·American Journal of Obstetrics and Gynecology·C G NilssonT Luukkainen
Apr 1, 1976·Contraception·C G NilssonT Luukkainen
Oct 1, 1992·Contraception·I Batar
Jan 1, 1991·Annals of the New York Academy of Sciences·T Luukkainen
May 1, 1991·Contraception·B JonssonP Eneroth
Jan 1, 1991·Geburtshilfe und Frauenheilkunde·C P Janisch, A Schubert
Apr 1, 1990·Annals of Medicine·T LuukkainenJ Toivonen
Jul 1, 1990·Contraception·I BarbosaE D Johansson
Sep 1, 1990·British Journal of Obstetrics and Gynaecology·H BuchanK McPherson
Jun 1, 1986·Fertility and Sterility·C G NilssonD N Robertson
Oct 1, 1988·British Journal of Obstetrics and Gynaecology·G E Bignardi
Jun 1, 1986·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·W YuanJ Fan
Sep 1, 1974·Fertility and Sterility·R C Jones
Jun 15, 1968·American Journal of Obstetrics and Gynecology·L L Doyle, T H Clewe
Dec 15, 1969·American Journal of Obstetrics and Gynecology·J A ZipperM Rivera
Feb 1, 1995·Contraception·H Van KetsF Martinez
Apr 1, 1993·Annals of Medicine·A FaúndesJ Díaz
Apr 1, 1993·Annals of Medicine·D R Mishell
Feb 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·W BoundsJ Guillebaud
Jan 1, 1996·Reproduction, Fertility, and Development·L RobleroF Zegers-Hochschild
Dec 1, 1996·Obstetrical & Gynecological Survey·M E OrtizC W Bardin
Jul 3, 1998·Contraception·K AnderssonI Milsom

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Citations

Nov 6, 2013·Antiviral Research·David R FriendMeredith R Clark
Feb 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lothar W KleinerYunbing Wang
Jan 7, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·David R Friend
Jan 18, 2011·Journal of Reproductive Immunology·E Dimitriadis, E Menkhorst
Mar 26, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Kirsten I BlackAli Kubba
Nov 12, 2015·Deutsches Ärzteblatt International·Florin-Andrei TaranSara Brucker

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