Contraceptive potential of RU 486 by ovulation inhibition: I. Pituitary versus ovarian action with blockade of estrogen-induced endometrial proliferation

Contraception
J F van UemG D Hodgen

Abstract

In previous studies, RU 486 administration arrested spontaneous folliculogenesis. To investigate the central versus peripheral effects of RU 486 on the ovarian/menstrual cycle, including endometrial proliferation, RU 486 was administered daily (10 mg/kg/day, im) from menstrual cycle day 3 or 7 to day 25 in normal adult cynomolgus monkeys receiving hMG treatment (37.5 IU/day) from days 3-8 (n = 6). RU 486 administration with hMG/hCG therapy did not inhibit ovarian response, as evidenced by steroidogenesis and ovulation. Nine of 23 oocytes retrieved by lavage or follicular aspiration at laparotomy after ovulation induction were morphologically classified as mature preovulatory status. Whereas an endometrial biopsy performed on cycle day 25 in control monkeys revealed an in phase mature secretory endometrium, histologic sections from RU 486 plus hMG/hCG treated females uniformly demonstrated atrophic to weakly proliferative endometrium on cycle day 25, despite serum estradiol levels greater than 300 pg/ml. Three months after the initial 25-day study endometrial biopsies revealed persistent atrophic endometrium, even though repeated ovulation induction with hMG/hCG therapy elevated serum estrogen concentrations. The findings prevai...Continue Reading

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Citations

Jun 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·D L CrombieM W Wang
Dec 12, 2003·Steroids·David T BairdAlistair R W Williams
Dec 12, 2003·Steroids·Sharon T CameronDavid T Baird
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Feb 17, 2001·The Journal of Steroid Biochemistry and Molecular Biology·S PalmerD W Combs
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Aug 5, 1993·The New England Journal of Medicine·I M Spitz, C W Bardin
Jan 15, 2003·Human Reproduction·D T BairdL Cheng
Jul 16, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Marisa CabezaCristina Revilla
Dec 5, 2012·Archiv der Pharmazie·Mariana GarridoMarisa Cabeza
Nov 1, 1993·Contraception·I M Spitz, C W Bardin
Apr 1, 1996·Baillière's Clinical Obstetrics and Gynaecology·M L SwahnM Bygdeman
Sep 1, 1995·American Journal of Obstetrics and Gynecology·R R KatkamC P Puri

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