Contraceptive potential of RU 486 by ovulation inhibition: II. Suppression of pituitary gonadotropin secretion in vitro

Contraception
J P WolfG D Hodgen

Abstract

That the antiprogestin RU 486 delays or inhibits the LH surge, and induces premature luteolysis in monkeys and women concurrent with a reduction in LH/FSH secretion has been reported. Whether this inhibition of gonadotropin release was a result of action at the hypothalamic and/or pituitary level is unknown. Here, we utilized a rat pituitary cell culture system to evaluate direct RU 486 actions on pituitary gonadotropin secretion in vitro. Cell cultures were primed with 10 nM estradiol for 48 h in order to maintain progesterone receptors. Basal and GnRH-induced secretion were evaluated after a 4-hour incubation period. The progesterone antagonist RU 486 inhibited GnRH-induced LH and FSH secretion in a dose-dependent manner, without affecting basal gonadotropin release. This inhibition of gonadotropin secretion was specific and antagonized by addition of progesterone in vitro.

Citations

Aug 5, 1993·The New England Journal of Medicine·I M Spitz, C W Bardin
Nov 2, 2012·Contraception·Kristina Gemzell-DanielssonLalitkumar P G L
Oct 12, 2010·Contraception·Kristina Gemzell-Danielsson
Nov 1, 1993·Contraception·I M Spitz, C W Bardin
Feb 1, 1993·Annals of Medicine·O Heikinheimo, R Kekkonen
Apr 1, 1990·Annals of Medicine·O HeikinheimoP Lähteenmäki

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