PMID: 9179454Apr 1, 1997Paper

Contraceptives for lactating women: a comparative trial of a progesterone-releasing vaginal ring and the copper T 380A IUD

Contraception
I SivinT M Jackanicz

Abstract

From approximately one week before normal ovulation resumes, lactating women require protection against pregnancy by a contraceptive that is safe for both infant and mother in a multicenter one-year study, the natural hormone, progesterone, delivered vaginally by a sequence of four contraceptive rings designed for continuous use, was evaluated as a contraceptive for nursing mothers in comparison with the Copper T 380A IUD. Individual rings release in effective average dose of 10 mg day for a 3 month period. Evaluation included measures of lactational performance as well as of contraceptive efficacy and safety to mother and child. Nine participating clinics enrolled 802 ring users and 734 IUD acceptors between postpartum days 29 and 63. Life table analyses were performed with parallel decrements for ring and IUD subjects. Continuation in the study and analysis required that subjects not stop breastfeeding. The ring, with a one-year pregnancy rate of 1.5 per 100, did not differ significantly from the IUD with respect to contraceptive effectiveness (p > 0.05). More than half of the ring subjects were continuing at 6 months post admission and a quarter (23.5 per hundred) were still using the ring and breastfeeding one year after ad...Continue Reading

References

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Citations

Jun 8, 2002·Obstetrics and Gynecology·Kathryn M CurtisUNKNOWN WHO Programme for Mapping Best Practices in Reproductive Health
Dec 8, 2000·Steroids·R MassaiH B Croxatto
Dec 8, 2000·Steroids·V BracheP Lähteenmäki
Dec 12, 2003·Steroids·Regine Sitruk-WareTheodore Jackanicz
Feb 24, 2001·Clinical Obstetrics and Gynecology·S A Ballagh
Sep 26, 2012·Antimicrobial Agents and Chemotherapy·Todd J JohnsonPatrick F Kiser
Dec 14, 2011·Antimicrobial Agents and Chemotherapy·Todd J JohnsonPatrick F Kiser
Oct 19, 2013·Pharmaceutical Research·Ignacio M HelblingJulio A Luna
Oct 9, 2012·Contraception·Vivian BracheAníbal Faundes
Oct 15, 2014·Clinical Obstetrics and Gynecology·Pamela A Royer, Kirtly P Jones
Sep 22, 2012·Contraception·Regine Sitruk-WareDaniel R Mishell
Nov 22, 2005·Expert Opinion on Drug Delivery·Regine Sitruk-Ware
Jan 7, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·David R Friend
Oct 12, 2010·Contraception·Vivian Brache, Anibal Faundes
Sep 22, 2015·Current Opinion in Obstetrics & Gynecology·Neha R Bhardwaj, Eve Espey
Jul 9, 2004·Fertility and Sterility·Nancy J AlexanderEdio Zampaglione
May 8, 2013·Climacteric : the Journal of the International Menopause Society·R Sitruk-Ware, M El-Etr
Apr 24, 2004·American Journal of Obstetrics and Gynecology·Elof D B Johansson, Regine Sitruk-Ware
Feb 9, 2010·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Diana MansourKristina Gemzell-Danielsson
Feb 3, 2018·Studies in Family Planning·Saumya RamaRaoJohn Townsend
Oct 6, 2018·Expert Opinion on Pharmacotherapy·Ilza MonteiroLuis Bahamondes
Jun 30, 2004·The Journal of Family Planning and Reproductive Health Care·UNKNOWN Faculty of Family Planning & Reproductive Health Care
Mar 10, 2004·The Journal of Family Planning and Reproductive Health Care·Gillian PenneyUNKNOWN Faculty of Family Planning and Reproductive Health Care Clinical Effectiveness Unit
Jul 21, 2020·Expert Opinion on Drug Delivery·Peter BoydR Karl Malcolm
Jan 1, 2015·Expert Review of Endocrinology & Metabolism·Regine Sitruk-Ware, Anita Nath

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