PMID: 3588345Mar 1, 1987Paper

Contractile and dilatory action of neuropeptides on isolated human mesenteric blood vessels

Peptides
K TörnebrandtC Owman

Abstract

Neuropeptide Y (NPY), substance P (SP), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP), lysyl-bradykinin, somatostatin, Met- and Leu-enkephalin were tested for their smooth muscle activity in isolated human mesenteric arteries and veins. Only NPY regularly contracted both arteries and veins. Alpha-adrenergic and 5-HT2 antagonists did not affect the response. Somatostatin contracted the veins, but not the arteries, in a variable but concentration-dependent way. The other neuropeptides were without contractile effect. CGRP, bradykinin, and SP regularly dilated, in a concentration-dependent way, both arteries and veins precontracted with prostaglandin F2 alpha or uridine triphosphate. CGRP and bradykinin were the most potent dilators. VIP and somatostatin usually caused a moderate dilatation in the arteries, whereas in the veins, somatostatin was without dilatory effect and the VIP-induced dilatation was irregular. In both types of vessels Met-enkephalin seldom gave any significant dilatation, and no response occurred in the presence of Leu-enkephalin or NPY. The SP-antagonist (D-Arg, D-Trp, Leu)-SP (spantide) caused a dextal shift of the concentration-response curves for SP, in the case of the art...Continue Reading

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Citations

Jan 1, 1990·Pharmacology & Therapeutics·M C MioneG Burnstock
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·M E Shomali, L Katznelson
Jan 10, 1998·British Journal of Pharmacology·R W AboudJ R Docherty
Feb 27, 2003·Journal of Cardiovascular Pharmacology·Hakima MechichePhilippe Devillier
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Jun 1, 1992·British Heart Journal·T N LuuM H Yacoub
Oct 25, 2002·Japanese Journal of Pharmacology·Emilio RuizTeresa Tejerina
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Jan 29, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hakima MechichePhilippe Devillier
Jul 23, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D De FontgallandS J H Brookes
Jun 22, 2015·Neuropeptides·János TajtiLászló Vécsei
May 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A McCormickA K Burroughs
Nov 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A McCormickA K Burroughs
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S B CurtisA M Buchan

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