PMID: 3588345Mar 1, 1987Paper

Contractile and dilatory action of neuropeptides on isolated human mesenteric blood vessels

K TörnebrandtC Owman


Neuropeptide Y (NPY), substance P (SP), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP), lysyl-bradykinin, somatostatin, Met- and Leu-enkephalin were tested for their smooth muscle activity in isolated human mesenteric arteries and veins. Only NPY regularly contracted both arteries and veins. Alpha-adrenergic and 5-HT2 antagonists did not affect the response. Somatostatin contracted the veins, but not the arteries, in a variable but concentration-dependent way. The other neuropeptides were without contractile effect. CGRP, bradykinin, and SP regularly dilated, in a concentration-dependent way, both arteries and veins precontracted with prostaglandin F2 alpha or uridine triphosphate. CGRP and bradykinin were the most potent dilators. VIP and somatostatin usually caused a moderate dilatation in the arteries, whereas in the veins, somatostatin was without dilatory effect and the VIP-induced dilatation was irregular. In both types of vessels Met-enkephalin seldom gave any significant dilatation, and no response occurred in the presence of Leu-enkephalin or NPY. The SP-antagonist (D-Arg, D-Trp, Leu)-SP (spantide) caused a dextal shift of the concentration-response curves for SP, in the case of the art...Continue Reading


Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Oct 1, 1976·European Journal of Pharmacology·J Knoll
Jan 3, 1985·Nature·S D BrainI MacIntyre
Oct 1, 1966·The British Journal of Surgery·A N Smith, I J Zeitlin
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergV Mutt
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·G BussolatiA Sapino
Sep 1, 1980·Acta Physiologica Scandinavica·P Hellstrand, J Järhult
Dec 1, 1982·British Journal of Pharmacology·R HåkansonS Leander
Jan 1, 1983·General Pharmacology·B Pernow
Aug 1, 1982·Molecular and Cellular Endocrinology·G RosselinW Rostène
Jan 1, 1983·Life Sciences·P IllesK Starke
Oct 1, 1984·British Journal of Pharmacology·L EdvinssonC Wahlestedt
May 1, 1981·Acta Physiologica Scandinavica·R UddmanF Sundler
Mar 7, 1964·Lancet·J A OATESD T MASON
Jun 6, 1931·The Journal of Physiology·U S V Euler, J H Gaddum

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