PMID: 9194693Jan 1, 1997Paper

Contractile and relaxant effects of dimaprit on guinea pig isolated intestinal cells

Life Sciences
G MoriniG Bertaccini

Abstract

The effect of the histamine H2 receptor agonist dimaprit on intestinal contractility was characterized on smooth muscle cells isolated from the longitudinal muscle of the guinea pig ileum. Dimaprit exerted two opposite effects on the contractility of isolated muscle cells: relaxation of cholecystokinin octapeptide (CCK-8)-induced contractions in the range of concentrations 10(-17)-10(-13) M and contraction at concentrations higher than 10(-13) M. The relaxant effect of dimaprit was totally prevented by the H2 blocker famotidine (10(-7) M), which, at the same time, enhanced the contractile effect of dimaprit, shifting to the left the concentration-response curve to the agonist. This contraction was not modified by the histamine H1 receptor antagonists pyrilamine and temelastine, tested both at 10(-7) M. By contrast, atropine 10(-8) M abolished the contractile effect of dimaprit, while leaving unchanged the response to CCK-8. Our results clearly indicate that longitudinal muscle cells of the guinea pig ileum possess inhibitory H2 receptors, which can be activated by very low concentrations of dimaprit; moreover, they revealed that dimaprit can have non-histaminergic effects, probably due to muscarinic receptor activation; however...Continue Reading

References

Oct 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·G BertacciniJ Zseli
Sep 1, 1981·The Journal of Pharmacy and Pharmacology·G Bertaccini, L Zappia
Sep 1, 1995·Digestive Diseases and Sciences·G Bertaccini, G Coruzzi
Feb 1, 1995·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·T GudermannG Schultz

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