Contractile effect of Sclerocarya birrea (A Rich) Hochst (Anacardiaceae) (Marula) leaf aqueous extract on rat and rabbit isolated vascular smooth muscles.

Cardiovascular Journal of Africa
Tariro MawozaPeter M O Owira

Abstract

Sclerocarya birrea (Anacardiaceae) is traditionally used for treating hypertension. The pharmacological effects of S birrea leaf aqueous extract (SBE) on rabbit and rat vascular smooth muscles were investigated in this study. Fresh S birrea leaves (1 kg) were air dried at 26 ± 1°C, milled, macerated in 2.5 l of distilled water for 48 hours, filtered, and the filtrate was concentrated in a rotary evaporator. Rat isolated portal vein preparations, as well as rabbit isolated endothelium-denuded and endothelium-intact descending thoracic aortic ring preparations were mounted in 30-ml Ugo Basile organ baths under physiological conditions, and challenged with SBE (50-400 mg/ml). The contractile effects of SBE and/or other reference drugs on the isolated vascular smooth muscle preparations were recorded by means of Ugo Basile's force-displacement transducers and Gemini recorders. SBE (50-400 mg/ml) caused a significant, concentration-dependent upward shift in baseline tone in the aortic ring preparations (p < 0.01-0.001). Indomethacin (20 µM) markedly attenuated the contractile effects of SBE in both the endothelium-intact and -denuded aortic rings, while N(G)-nitro-(L)-arginine methyl ester (L-NAME, 100 µM) significantly (p < 0.05) i...Continue Reading

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Apr 17, 2009·The Journal of Nutritional Biochemistry·José Gil-Longo, Cristina González-Vázquez

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Citations

Dec 27, 2012·BMC Complementary and Alternative Medicine·Watcho PierreKamanyi Albert
Mar 1, 2012·Journal of Pharmacy & Bioallied Sciences·Vasim KhanK K Pillai
May 20, 2015·Toxicology Letters·Denisa MarginăAristidis M Tsatsakis
Dec 21, 2018·Current Medicinal Chemistry·Manuel SánchezJuan Duarte
Dec 10, 2019·Journal of Ethnopharmacology·S van Vuuren, L Frank

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