Contractile function of single muscle fibers after hindlimb unweighting in aged rats

Journal of Applied Physiology
LaDora V Thompson, J A Shoeman

Abstract

This investigation determined how muscle atrophy produced by hindlimb unweighting (HU) alters the contractile function of single muscle fibers from older animals (30 mo). After 1 wk of HU, small bundles of fibers were isolated from the soleus muscles and the deep region of the lateral head of the gastrocnemius muscles. Single glycerinated fibers were suspended between a motor lever and force transducer, functional properties were studied, and the myosin heavy chain (MHC) composition was determined electrophoretically. After HU, the diameter of type I MHC fibers of the soleus declined (88 +/- 2 vs. 80 +/- 4 microns) and reductions were observed in peak active force (47 +/- 3 vs. 28 +/- 3 mg) and peak specific tension (Po; 80 +/- 5 vs. 56 +/- 5 kN/m2). The maximal unloaded shortening velocity increased. The type I MHC fibers from the gastrocnemius showed reductions in diameter (14%), peak active force (41%), and Po (24%), whereas the type IIa MHC fibers showed reductions in peak active force and Po. Thus 1 wk of inactivity has a significant effect on the force-generating capacity of single skeletal muscle fibers from older animals in a fiber type-specific manner (type I MHC > type IIa MHC > type I-IIa MHC). The decline in the fun...Continue Reading

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Citations

Jan 24, 2004·Biological Research for Nursing·Alissa Guildner GehrkeLaDora V Thompson
Feb 27, 2003·Aging Clinical and Experimental Research·Jon J Groskreutz, LaDora V Thompson
Dec 17, 2019·Acta Physiologica·Rizwan QaisarAdel B Elmoselhi
May 4, 2004·Journal of Applied Physiology·Jason C GalleglyEsther E Dupont-Versteegden
Oct 30, 2012·Journal of Applied Physiology·Jong-Hee Kim, Ladora V Thompson
Jun 4, 2014·Acta Physiologica·M MaffeiM Canepari
Aug 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Esther E Dupont-VersteegdenCharlotte A Peterson
May 13, 2006·Journal of Applied Physiology·Sheng ZhongLaDora V Thompson

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