PMID: 4204972Feb 1, 1974

"Contractile interstitial cells" in pulmonary alveolar septa: a possible regulator of ventilation-perfusion ratio? Ultrastructural, immunofluorescence, and in vitro studies

The Journal of Cell Biology
Y KapanciGiulio Gabbiani

Abstract

In the lungs of healthy rats, humans, lambs, and monkeys, about 50% of the alveolar interstitial cells-resembling fibroblasts-contain bundles of fibrils measuring 30-80 A in diameter. Immunofluorescence studies on frozen sections of rat lung demonstrate that many interstitial cells bind sera containing antiactin antibodies. On account of these two sets of findings and our additional in vitro studies suggesting alveolar tissue contraction due to hypoxia or epinephrine, we postulate that the alveolar septa contain contractile cells different from that of smooth muscle. For these cells we propose the name of "contractile interstitial cells." Such cells lie within the thick portion of the air-blood barrier and around the pre- or postcapillary vessels. Hence it is possible that they play a role in the autoregulation of ventilation/perfusion (V/Q) ratio, particularly in hypoxic pulmonary hypertension. These findings, demonstrating a contractile system other than bronchial and arterial smooth muscle, suggest that the alveolus should no more be conceived as a passive "organ."

References

Nov 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·B J HirschelG Majno
Apr 1, 1972·The Journal of Experimental Medicine·Giulio GabbianiG Majno
Jan 1, 1972·Journal of Ultrastructure Research·C Kuhn, E H Finke
May 1, 1971·Archives of Internal Medicine·J Gil
Apr 1, 1972·Angiology·S Rodbard, S Kira
Jul 1, 1966·Japanese Heart Journal·S Rodbard, S Kira
Apr 1, 1968·Journal of Ultrastructure Research·B Meyrick, L Reid
Sep 1, 1969·The Journal of Cell Biology·G MajnoM Leventhal
Jun 1, 1966·Journal of Ultrastructure Research·W E Stehbens
Oct 1, 1966·American Heart Journal·S Rodbard, S Kira
Oct 1, 1953·The Anatomical Record·F N LOW
Nov 25, 1955·The Journal of Biophysical and Biochemical Cytology·E YAMADA
Feb 2, 1963·JAMA : the Journal of the American Medical Association·G CORSSEN

Citations

Jan 1, 1979·The Anatomical Record·B Meyrick, L Reid
Jan 1, 1992·Cell Motility and the Cytoskeleton·K O LeslieR Low
Aug 1, 1992·Journal of Applied Toxicology : JAT·R S SakaeP H N Saldiva
Sep 25, 1975·Anatomy and Embryology·A J Collet, G Des Biens
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·H K Müller-HermelinkC Feldmann
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·G E Novotny, H Pau
Dec 1, 1987·Inflammation·P SiroisM Lauzière
Nov 15, 1975·Experientia·N ReverdinY Kapanci
May 1, 1981·Agents and Actions·P Eyre, K B Mirbahar
Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J GrohA E Goetz
Nov 20, 2012·Lung·Jai Prakash MuyalHarsh Bhardwaj
Sep 1, 1989·Journal of Anesthesia·Y FujitaM Takaori
Feb 15, 1979·European Journal of Pharmacology·H W Mitchell, M A Denborough
Jun 10, 1981·European Journal of Pharmacology·J BlackJ Shaw
Feb 17, 1984·European Journal of Pharmacology·K VincencJ Shaw
Jul 1, 1981·Respiration Physiology·E M ScarpelliB C Clutario
Nov 1, 1981·Respiration Physiology·A J SuggettD Bee
Mar 1, 1982·Respiration Physiology·T MiyazawaO Nishida
Jan 1, 1982·Respiration Physiology·D Wangensteen, Ewald R Weibel
Jul 1, 1990·Respiration Physiology·I Mayers, D H Johnson
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R G GoldieJ W Paterson
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A WartonJ W Paterson
Nov 1, 1993·Journal of Pharmacological and Toxicological Methods·A R Hulsmann, J C de Jongste
Apr 1, 1997·Respiration Physiology·M DolhnikoffMarco Aurélio Martins
Mar 28, 2003·Respiratory Physiology & Neurobiology·José Henrique Leite-JúniorWalter A Zin
Mar 31, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daisuke MatsubaraToshiro Niki
Oct 24, 1974·The New England Journal of Medicine·A P Fishman, G G Pietra
Jun 1, 1979·The Journal of Experimental Medicine·A B van oud Alblas, R van Furth
Oct 1, 1993·British Journal of Pharmacology
Apr 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T Lombardi, P R Morgan
Jun 9, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anne-Karina T Perl, Emily Gale
Sep 12, 2013·BioMed Research International·Priyadharshanan AriyaratnamAlyn H Morice
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·M DolhnikoffM S Ludwig
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·M DolhnikoffM S Ludwig
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·R JonesW Steudel
Sep 6, 2000·American Journal of Respiratory Cell and Molecular Biology·D P WendelD Y Li
Dec 1, 1990·American Journal of Respiratory Cell and Molecular Biology·R A Schmidt, A M Gown
Jan 12, 2010·American Journal of Respiratory Cell and Molecular Biology·Dmitri V PechkovskyDarryl A Knight
Jun 2, 2012·American Journal of Respiratory Cell and Molecular Biology·Leiling ChenAnne-Karina T Perl
Jun 1, 1978·The Journal of Clinical Investigation·J M Drazen, M W Schneider
Oct 1, 1982·The Journal of Clinical Investigation·P B BittermanR G Crystal
Nov 6, 2002·The Journal of Clinical Investigation·Desi PanL Schuger
Apr 1, 1984·Environmental Health Perspectives·R Breeze, M Turk
May 4, 2010·PloS One·Robert H BrownWayne Mitzner
Oct 21, 2011·Critical Reviews in Biomedical Engineering·David W Kaczka, Raffaele L Dellacá
Jan 1, 2014·Respiratory Physiology & Neurobiology·Renato Fraga RighettiIolanda de Fátima Lopes Calvo Tibério
Sep 28, 2001·Biochemical and Biophysical Research Communications·K EndoK Watanabe
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·J J Coalson
Jun 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Zarah J PuaMary E Sunday
Feb 12, 1998·The Journal of Cell Biology·D C Mayer, L A Leinwand
Jan 1, 1986·Experimental Lung Research·R H Goldstein, A Fine
Aug 1, 1981·Experimental Lung Research·J N Evans, K B Adler
Dec 1, 1978·The Anatomical Record·C Vaccaro, J S Brody
Mar 1, 1990·Chest·F HaasH Pineda
Sep 1, 1990·The Anatomical Record·P H Burri, M R Tarek
May 1, 1993·The Anatomical Record·J M PolakY E Miller
Mar 1, 1993·Chest·D A Kaminsky, C G Irvin
May 1, 1983·Chest·J N EvansK B Adler
Sep 1, 1989·Chest·G BaltopoulosC Roussos
Dec 4, 2015·Developmental Biology·Kelsey BranchfieldXin Sun
Jul 1, 1979·The Journal of Pathology·P A Dervan, J A Hayes
Jul 1, 1979·The Journal of Pathology·B CorrinL Weaver
Jun 14, 2012·Respiratory Physiology & Neurobiology·David W Kaczka, Jennifer L Smallwood
Jan 1, 1987·Progress in Histochemistry and Cytochemistry·C Meban
Jun 15, 2000·The American Journal of Pathology·D LevineL M Schnapp
Jul 1, 1980·Journal of the American Academy of Dermatology·W D JamesR B Odom
May 11, 2010·Experimental Cell Research·Lysianne Follonier CastellaBoris Hinz
May 19, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S de Magalhães SimõesM Dolhnikoff
Jan 14, 2004·British Journal of Pharmacology·Kiyoto SakataMagnus Bäck
Apr 20, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Namjin Kim, Thiennu H Vu
Aug 13, 2013·Periodontology 2000·Boris Hinz
Feb 22, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Emma L Rawlins
Aug 1, 1981·Journal of Ultrastructure Research·J Gil, J M McNiff
Jul 15, 2015·European Journal of Pharmacology·Fatma AydinogluNuran Ogulener
Sep 1, 1974·Microvascular Research·Ewald R Weibel
Oct 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Prié, P Sirois
Apr 1, 1992·Experimental Eye Research·E TammJ W Rohen
Nov 1, 1983·The Journal of Surgical Research·J AliH S Goldberg
Aug 1, 1982·British Journal of Pharmacology·R G GoldieJ L Wale
Apr 1, 1985·The Anatomical Record·G C Winkler, N F Cheville
Jan 1, 1982·Annals of the New York Academy of Sciences·J Gil
Jan 1, 1982·Annals of the New York Academy of Sciences·L Reid, B Meyrick
May 1, 1985·British Journal of Pharmacology·M J FinneyC G Persson
Jan 1, 1988·Pediatric Pulmonology·M F DiMaioM Kattan
Oct 1, 1985·British Journal of Pharmacology·C Advenier, J L Freslon
Jul 1, 1986·British Journal of Pharmacology·R G GoldieD Spina
Sep 1, 1983·British Journal of Pharmacology·R A Nayler, M P Sparrow
Sep 1, 1983·British Journal of Pharmacology·J F BertramJ W Paterson
Oct 1, 1989·International Journal of Oral and Maxillofacial Surgery·D DayanR David
Aug 1, 1990·Differentiation; Research in Biological Diversity·K O LeslieR B Low
Jan 12, 2013·Respiratory Physiology & Neurobiology·Michael J EmeryErik R Swenson
May 1, 1995·Respiratory Medicine·V Brusasco, R Pellegrino
Jan 28, 2014·Advanced Drug Delivery Reviews·Hiroshi Nishihara
Jan 15, 2015·Anesthesiology·Andrew B Lumb, Peter Slinger
Jul 24, 2003·The American Journal of Pathology·Bin TianCraig Henke
Dec 17, 2016·Cell and Tissue Research·Ewald R Weibel
May 5, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Plamen Bokov, Christophe Delclaux
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·K T Weber, Y Sun
Apr 1, 1976·Circulation Research·A P Fishman
Apr 1, 1982·Circulation Research·R GrahamH S Goldberg
Aug 9, 2017·PloS One·Stacey R BoserFrancis H Y Green
Nov 6, 2018·Histochemistry and Cell Biology·Lars Knudsen, Matthias Ochs
Jan 25, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Juwon ParkMichelle D Tallquist
Jun 1, 1978·The Anatomical Record·R Rudolph, M Woodward
Jun 1, 1987·Journal of Clinical Pathology·P I RichmanW F Bodmer
Jul 9, 2009·Physiological Reviews·Débora S Faffe, Walter A Zin
Jun 23, 1998·Canadian Journal of Physiology and Pharmacology·T Nagase, M S Ludwig
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Mar 29, 2003·Physiological Reviews·Alan R BurnsDavid C Walker
May 1, 1997·Journal of Applied Physiology·David W KaczkaK R Lutchen
Mar 5, 1998·The American Journal of Physiology·L E FisherJ D Catravas
Jan 14, 1999·Journal of Applied Physiology·H SakaiM Mishima
Mar 15, 2001·Journal of Applied Physiology·F R ShardonofskyJ R Rodarte
Jun 16, 2001·Journal of Applied Physiology·E H OldmixonF G Hoppin
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Václav HamplStephen L Archer
Jan 14, 1999·Journal of Applied Physiology·F G Salerno, M S Ludwig
Jul 9, 1998·Journal of Applied Physiology·F G Salerno, M S Ludwig
Oct 15, 2011·Journal of Applied Physiology·Kal E WatsonRobert L Conhaim
Nov 28, 2019·PloS One·Manuel Rodríguez-MartínezVianney Guerreo-Ojeda
Nov 30, 2019·Frontiers in Bioengineering and Biotechnology·Akiko Mammoto, Tadanori Mammoto
Oct 1, 1979·The Journal of Pharmacy and Pharmacology·N Chand, L DeRoth
May 12, 1998·The American Journal of Physiology·C ColemanD Warburton
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A V CloughC A Dawson
Jul 3, 2013·Journal of Applied Physiology·David W KaczkaRobert H Brown
Jan 1, 1984·The American Journal of Physiology·J Gil, J M McNiff

Related Concepts

Metazoa
Anoxemia
Anthropoidea
Bos indicus
Epinephrine Acetate
Tetraiodofluorescein
Immunofluorescence Assay
Melting
Goat
Cytochemistry

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.