In the lungs of healthy rats, humans, lambs, and monkeys, about 50% of the alveolar interstitial cells-resembling fibroblasts-contain bundles of fibrils measuring 30-80 A in diameter. Immunofluorescence studies on frozen sections of rat lung demonstrate that many interstitial cells bind sera containing antiactin antibodies. On account of these two sets of findings and our additional in vitro studies suggesting alveolar tissue contraction due to hypoxia or epinephrine, we postulate that the alveolar septa contain contractile cells different from that of smooth muscle. For these cells we propose the name of "contractile interstitial cells." Such cells lie within the thick portion of the air-blood barrier and around the pre- or postcapillary vessels. Hence it is possible that they play a role in the autoregulation of ventilation/perfusion (V/Q) ratio, particularly in hypoxic pulmonary hypertension. These findings, demonstrating a contractile system other than bronchial and arterial smooth muscle, suggest that the alveolus should no more be conceived as a passive "organ."
Hypoxia and pulmonary vascular resistance. The relative effects of pulmonary arterial and alveolar PO2
Changing concepts of the mechanism of pulmonary atelectasis. A study of smooth muscle elements in the human lung
Freeze-fracture demonstration of communicating junctions between interstitial cells of the pulmonary interalveolar septa
Fibroblastic and dendritic reticulum cells of lymphoid tissue. Ultrastructural, histochemical, and 3H-thymidine labeling studies
An experimental model for simultaneous quantitative analysis of pulmonary micro- and macrocirculation during unilateral hypoxia in vivo
Assessment of induced bronchoconstriction in anesthetized cats by the end-inflation occlusion method
Contribution of vascular smooth muscle to contractile responses of guinea-pig isolated lung parenchymal strips
Theophylline's inhibition of antigen-induced contraction of human parenchymal strips is independent of adenosine antagonism
Effects of prostaglandin endoperoxide analogs on contractile elements in lung and gastrointestinal tract
A pharmacological and ultrastructural study of alveolar contractile tissue in toad (Bu fo marinus) lung
Effects of adrenaline and carbachol on the morphology of alveolar contractile cells in the lung of the toad (Bufo marinus)
Contractile actions of proteinase-activated receptor-derived polypeptides in guinea-pig gastric and lung parenchymal strips: evidence for distinct receptor systems
Interstitial lung diseases of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract (first of two parts)
The isolated lung strip and single open tracheal ring: a convenient combination for characterizing Schultz Dale anaphylactic contractions in the peripheral and central airways of the guinea-pig
Pharmacological and histological examinations of regional differences of guinea-pig lung: a role of pleural surface smooth muscle in lung strip contraction
Non-adrenergic, non-cholinergic neural activation in guinea-pig bronchi: powerful and frequency-dependent stabilizing effect on tone
Predominance of endothelinA (ETA) receptors in ovine airway smooth muscle and their mediation of ET-1-induced contraction
The distribution and density of receptor subtypes for endothelin-1 in peripheral lung of the rat, guinea-pig and pig
Characterization of the anatomical structures involved in the contractile response of the rat lung periphery
Muscarinic blockade of methacholine induced airway and parenchymal lung responses in anaesthetised rats
Malotilate prevents accumulation of type III pN-collagen, type IV collagen, and laminin in carbon tetrachloride-induced pulmonary fibrosis in rats
Human lung parenchyma but not proximal bronchi produces fibroblasts with enhanced TGF-beta signaling and alpha-SMA expression
Dynamic regulation of platelet-derived growth factor receptor α expression in alveolar fibroblasts during realveolarization
Comparative responses of tracheal spirals and parenchymal strips to histamine and carbachol in vitro
PDGF-Ralpha gene expression predicts proliferation, but PDGF-A suppresses transdifferentiation of neonatal mouse lung myofibroblasts
Metabolism of vitamin A affected by prostaglandin F synthase in contractile interstitial cells of bovine lung
Histochemical analyses of altered fetal lung development following single vs multiple courses of antenatal steroids
Smooth muscle myosin in precursor and mature smooth muscle cells in normal pulmonary arteries and the effect of hypoxia
Sequential changes in lung morphology during the repair of acute oxygen-induced lung injury in adult rats
Correlative study of adult respiratory distress syndrome by light, scanning, and transmission electron microscopy
Bronchopulmonary dysplasia: a correlative study by light, scanning, and transmission electron microscopy
Morphologic and functional characteristics of subpopulations of murine lung fibroblasts grown in vitro
Platelet-derived growth factor: a key regulator of connective tissue cells in embryogenesis and pathogenesis
Constant-phase descriptions of canine lung, chest wall, and total respiratory system viscoelasticity: effects of distending pressure
Structural patterns and histological behaviour of experimental sarcomas. I. General considerations, histology and histochemistry
Different strains of mice present distinct lung tissue mechanics and extracellular matrix composition in a model of chronic allergic asthma
Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue
The relation between effects of adenosine, theophylline and enprofylline on the contractility of sensitized guinea-pig lung strips
Beta-adrenoceptor heterogeneity in guinea-pig airways: comparison of functional and receptor labelling studies
Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2
Induction of apoptosis in human lung fibroblasts and peripheral lymphocytes in vitro by Shosaiko-to derived phenolic metabolites
Relationship of spasmogenic and smooth muscle relaxant peptides from normal lung to other vasoactive compounds
Regional CO2 tension quantitatively mediates homeostatic redistribution of ventilation following acute pulmonary thromboembolism in pigs
Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model
Inhibition of vascular and epithelial differentiation in murine nitrofen-induced diaphragmatic hernia
Dynamic properties of lung parenchyma: mechanical contributions of fiber network and interstitial cells
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