PMID: 2503412Jun 1, 1989Paper

Contractile properties of cardiac papillary muscle in streptozotocin-diabetic rats and the effects of aldose reductase inhibition

Diabetologia
N E CameronS Robertson

Abstract

This study examined the preventative effect of an aldose reductase inhibitor, ponalrestat, on contractile properties of heart left ventricular papillary muscles in rats having streptozotocin induced diabetes for 13 weeks. Both contraction and relaxation were slowed by diabetes. The time to reach peak twitch tension was increased by 21%, and the time to relax to half peak tension was increased by 29% (p less than 0.01, respectively compared to normal control animals). With ponalrestat treatment, the increase in contraction time was only 11%, and relaxation was only slowed by 4% (p less than 0.05 and p less than 0.01, respectively compared to diabetic controls). Diabetes also reduced maximum rates of contraction (13%) and relaxation (19%) and prolonged the time taken to reach peak relaxation rate (36%, p less than 0.01). Ponalrestat had no effect on maximum contraction rates but was particularly effective in normalising relaxation rates (p less than 0.01). Deficiencies with diabetes were noted over a range of stimulation frequencies (0.1-4.0 Hz), and ponalrestat treatment was beneficial except at the highest rates. Diabetes and ponalrestat effects were observed over a temperature range of 25-37 degrees C. Ventricular sorbitol lev...Continue Reading

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Citations

Sep 18, 1991·Molecular and Cellular Biochemistry·S W Schaffer
Jul 1, 2009·The Journal of Physiological Sciences : JPS·Adolfo Virgen-OrtizJ Muñiz
Feb 1, 1994·Mechanisms of Ageing and Development·M FunasakoM Ohata
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Jun 25, 2010·American Journal of Physiology. Cell Physiology·Wai Ho TangStephen Sum Man Chung
Jan 31, 2002·Drugs·Steven J Lavine, Steven D Gellman
Nov 23, 2006·Journal of the Peripheral Nervous System : JPNS·Yun JiangAndrew P Mizisin
Nov 15, 1997·Metabolism: Clinical and Experimental·S LalB S Szwergold
Jul 22, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Vishal BhatiaSandeep Dhindsa
Jan 18, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sarah E HoganRoger M Ilagan
Oct 1, 1992·Metabolism: Clinical and Experimental·A KashiwagiY Saeki

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