PMID: 3759756Sep 1, 1986Paper

Contractile properties of the human diaphragm in vivo

Journal of Applied Physiology
F BellemareJ J Woods

Abstract

The mechanical properties of the human diaphragm have been studied at fractional residual capacity in normal seated subjects with closed glottis. The transdiaphragmatic pressure (Pdi) developed in response to single shocks or to trains of stimuli at increasing frequency was approximately 3 times greater during bilateral than unilateral stimulation. During unilateral phrenic nerve stimulation the Pdi twitches increased as the interval (0-200 ms) of a preceding conditioning stimulus to the contralateral phrenic nerve was decreased suggesting that the two hemidiaphragms are mechanically coupled in series. The contraction time and half-relaxation time of single bilateral twitches as well as the Pdi-frequency relationship (5-35 Hz) during bilateral tetanic stimulation indicate that the contractile properties of the human diaphragm are intermediate between those of fast- and slow-twitch muscle fibers. The results suggest that the contractile properties of the human diaphragm are well illustrated by single bilateral twitches recorded from the relaxed muscle, but that the responses to unilateral stimulation are misleading due to distortion by abnormal changes in the muscle geometry.

Citations

Apr 16, 1998·Medical & Biological Engineering & Computing·D ChenF Bellemare
Apr 8, 2003·Journal of Applied Physiology·Andre De TroyerPierre Scillia
Jun 4, 2005·Journal of Applied Physiology·André De TroyerPierre Scillia
Jun 20, 2006·Journal of Applied Physiology·André De Troyer, Dimitri Leduc
May 5, 1998·Medicine and Science in Sports and Exercise·M A BabcockJ A Dempsey
Jun 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·J G HoustonI Bone
Dec 4, 2002·Pediatric Pulmonology·Gabriel DimitriouGerrard F Rafferty
Jun 21, 2005·Pediatric Pulmonology·Gerrard F RaffertyAnne Greenough
Sep 1, 1996·Medicine and Science in Sports and Exercise·G A FarkasD F Rochester
Feb 1, 1996·Intensive Care Medicine·C Roussos, S Zakynthinos
Oct 7, 1998·Journal of Applied Physiology·M I PolkeyJ Moxham
Jun 12, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Gerrard F. RaffertyJohn Moxham
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society/European Respiratory Society
May 29, 2014·Intensive Care Medicine·Franco LaghiMartin J Tobin
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Sep 26, 1991·The New England Journal of Medicine·T SimilowskiF Bellemare
Aug 3, 2018·BMC Pulmonary Medicine·Mayra Caleffi-PereiraAndré Luís Pereira Albuquerque

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