Contractile responses in spontaneously diabetic mice. II. Effect of cholestyramine on enhanced contractile response of aorta to norepinephrine in C57BL/KsJ (db/db) mice

General Pharmacology
N Kanie, K Kamata

Abstract

To examine the possible role of low-density lipoprotein (LDL) cholesterol in the enhanced norepinephrine (NE)-induced contractile response seen in spontaneously diabetic mice (db/db mice), we examined the effect of chronic administration of cholestyramine on the NE-induced contraction. Although chronic cholestyramine (300 mg/kg, po for 1 month) significantly lowered total cholesterol, high-density lipoprotein (HDL) cholesterol, LDL cholesterol, and triglyceride, the plasma glucose and insulin levels were unaffected. The enhanced NE response in diabetic mice was not affected by the chronic administration of cholestyramine. The K(+)-induced contractile response was not different among nondiabetic, diabetic, and diabetic mice chronically treated with cholestyramine. These results suggest that neither LDL cholesterol nor triglyceride is involved in the enhancement of the NE-induced contractile response seen in spontaneously diabetic mice.

References

Apr 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R C SharmaQ Jiao
Dec 1, 1990·Canadian Journal of Physiology and Pharmacology·R A RhoadesR A Meiss
Jul 1, 1987·Canadian Journal of Physiology and Pharmacology·D K Agrawal, J H McNeill
Aug 9, 1988·European Journal of Pharmacology·K H Harris, K M MacLeod
Jan 16, 1989·Biochemical and Biophysical Research Communications·R M Palmer, S Moncada
Dec 2, 1986·European Journal of Pharmacology·Y OyamaM Kanno
Apr 1, 1967·Diabetologia·D L Coleman, K P Hummel
Sep 2, 1966·Science·K P HummelD L Coleman
Dec 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·I Lues, H J Schümann
Nov 1, 1983·The Journal of Surgical Research·R H Bell, R J Hye
Jan 1, 1984·British Journal of Pharmacology·C EglèmeR C Miller
Jun 1, 1993·The Journal of Clinical Investigation·Y OharaD G Harrison
Oct 1, 1996·British Journal of Pharmacology·K Kamata, T Kobayashi
Oct 17, 1998·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P SrivastavaM Dikshit
Mar 17, 1999·European Journal of Pharmacology·T Kobayashi, K Kamata

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Citations

Mar 5, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Nada SallamIsmail Laher
Apr 28, 2010·Journal of Cardiovascular Pharmacology·Richard A Cohen, XiaoYong Tong
Dec 6, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Wen SuMing C Gong
Oct 19, 2011·Experimental Diabetes Research·Saeid GolbidiIsmail Laher
Aug 19, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Wen SuMing C Gong
Aug 15, 2009·Journal of Applied Physiology·R Daniel Rudic, David J Fulton
Nov 1, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Gopal V Velmurugan, Carl White
Mar 16, 2021·Current Opinion in Pharmacology·Tianfei HouMing C Gong

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