Nov 1, 1977

Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relations

W GrossmanL H Green


End-systolic pressure (PES), volume (VES), wall tension (TES) and circumference (CES) of the human left ventricle were studied at cardiac catheterization in 24 subjects with varying degrees of left ventricular dysfunction. Acute alterations in systolic load consistently resulted in changes in VES and CES, with a smaller volume and circumference characterizing the lower systolic load in each subject. End systolic pressure-volume lines were constructed by plotting PES against VES at the higher and lower systolic load in each subject. The slope of the resultant lines was considerably steeper for normal than for poorly contractile left ventricles. Vo, the volume axis intercept of the line (i.e., the theoretical VES at PES = O) was significantly smaller for normal than for poorly contractile ventricles. Similar findings were noted for Co, the theoretic end-systolic circumference at zero end-systolic ventricular wall tension. Post-extrasystolic potentiation resulted in decreased VES and CES with no change in PES and only a slight fall in TES. In conclusion, end-systolic pressure-volume and tension-circumference relations reflect the contractile state of left ventricular myocardium. Quantitation of these relationships may provide a us...Continue Reading

  • References16
  • Citations303


  • References16
  • Citations303


Mentioned in this Paper

Myocardial Contraction
Myocardium of Left Ventricle
Metoxamine Wellcome
Left Ventricular Structure
Diastolic Blood Pressure
Ventricular Dysfunction, Left
Cardiac Catheterization Procedures

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