PMID: 9172075Jun 1, 1997Paper

Contractility and myosin isoform compositions of skeletal muscles and muscle cells from rats treated with thyroid hormone for 0, 4 and 8 weeks

Journal of Muscle Research and Cell Motility
X Li, L Larsson

Abstract

The effects of 4 and 8 weeks of thyroid hormone (3,5,3'-triiodothyronine, T3) treatment on skeletal muscles of young (3-6 months) male Wistar rats were investigated in the present study. In the slow-twitch soleus, contraction and half-relaxation times of the isometric twitch were significantly shorter in hyperthyroid rats than in the control group, and twitch duration was shorter in rats treated with T3 for 8 weeks than for 4 weeks. All single soleus muscle fibres from hyperthyroid rats co-expressed types I and IIA myosin heavy chains (type I/IIA fibres) or type I, IIA and IIX myosin heavy chains (type I/IIAX fibres), while only type I MyHC fibres were isolated from the controls. A significantly higher content of type IIA myosin heavy chain and fast myosin light chain isoforms was observed in soleus fibres from the 8-week than from 4-week T3 group. There was no significant difference in maximum velocity of unloaded shortening (V0) between type I myosin heavy chain fibres from controls (1.12 +/- 0.46 muscle lengths s-1, n = 48) and type I/IIA myosin heavy chain fibres from the 4-1.09 +/- 0.36 muscle length s-1, n = 33) and 8-week (1.03 +/- 0.31 muscle lengths s(-1), n = 31) groups, but type I/IIAX fibres from the 8-week T3 group...Continue Reading

Citations

Jun 5, 1998·The American Journal of Physiology·F HaddadK M Baldwin
Oct 24, 2002·Acta Physiologica Scandinavica·J P WahrmannA T Dinh-Xuan
Sep 18, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P PircherL Larsson
Jun 24, 2004·Canadian Journal of Physiology and Pharmacology·Yadhu N SinghJames A Burbach
Jul 27, 2014·The Journal of Endocrinology·Michael Rosenbaum, Rudolph L Leibel

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