Contractility changes of the deep dorsal penile vein due to serotonin

The Journal of Urology
A A EsenZ Kirkali

Abstract

Penile erection is a complex neurovascular phenomenon that takes place with the active contribution of arterial and sinusoidal structures. However, some authors claim that larger veins including the deep dorsal veins that produce contractions, might be involved in the physiology of erection. This study was designed to clarify the contractile properties of deep dorsal penile veins (DDPV). The effect of serotonin (5-HT), noradrenaline (NA), adenosine triphosphate (ATP) and acethylcholine (Ach) on the isolated DDPVs of 16 impotent men, 9 with veno-occlusive dysfunction and 7 without venous leakage, and 5 potent men (controls) who underwent radical prostatectomy, were examined in vitro. Although NA, ATP and Ach had no effect, 5-HT produced concentration-dependent contractions. Emax and pEC50 of 5-HT were 411 +/- 10 mg., 5.92 +/- 0.25; 1020 +/- 260 mg., 5.83 +/- 0.24 and 160 +/- 40 mg., 6.4 +/- 0.22 in controls and patients who had venous leakage and no venous leakage, respectively. Samples of controls were contracted only with 5-HT2 agonist, DOI (pEC50 = 5.63 +/- 0.02), and these contractions were antagonized with 5-HT2 antagonist ketanserin. On the other hand, both DOI (pEC50 = 6.30 +/- 0.77) and 5-HT1 agonist, 5-CT (pEC50 = 6.23 ...Continue Reading

References

Dec 1, 1991·British Journal of Pharmacology·S TadipatriP R Saxena
Dec 11, 1991·Journal of Cardiovascular Pharmacology·C T HarkerJ M Porter
Jul 1, 1991·Journal of Vascular Surgery·Z S RadicP O Hagen
Nov 1, 1990·British Journal of Pharmacology·J P Finberg, Y Vardi
Dec 14, 1989·The New England Journal of Medicine·R J KraneI Saenz de Tejada
May 1, 1987·The Journal of Urology·T F Lue, E A Tanagho

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Citations

Oct 30, 2010·The Journal of Sexual Medicine·Arthur L BurnettZhong C Xin
Jun 8, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M A KhanR J Morgan
Mar 1, 2008·American Journal of Men's Health·David H W LauDimitri P Mikhailidis
Apr 30, 2002·International Journal of Impotence Research·A C MartínezS Benedito
Apr 2, 2004·International Journal of Impotence Research·P RecioM Hernández
Oct 18, 2007·Urologia Internationalis·David H W LauDimitri P Mikhailidis

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