Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?

Immunological Reviews
Sema KurtulusDavid Hildeman

Abstract

Maintenance of T-cell homeostasis is critical for normal functioning of the immune system. After thymocyte selection, T cells enter the peripheral lymphoid organs, where they are maintained as naive cells. Transient disruption of homeostasis occurs when naive T cells undergo antigen-driven expansion and acquire effector functions. Effector T cells then either undergo apoptosis (i.e. contraction at the population level) or survive to become memory cells. This apoptotic process is crucial: it resets T-cell homeostasis, promotes protective immunity, and limits autoimmunity. Although initial studies using in vitro models supported a role for death receptor signaling, more recent in vivo studies have implicated Bcl-2 family members as being critical for the culling of T-cell responses. While several Bcl-2 family members likely contribute to T-cell contraction, the pro-apoptotic molecule Bim and its anti-apoptotic antagonist Bcl-2 are essential regulators of the process. This review discusses the progress made in our understanding of the mechanisms underlying contraction of T-cell responses and how some cells avoid this cell death and become memory T cells.

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Citations

Apr 6, 2013·Cell Death and Differentiation·P TripathiD A Hildeman
Nov 29, 2011·Nature·Michael D RosenblumAbul K Abbas
Apr 29, 2011·Current Opinion in Immunology·Justin J Taylor, Marc K Jenkins
Oct 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HuS I Alexander
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Apr 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sema KurtulusDavid A Hildeman
Nov 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karin M KnudsonEmma Teixeiro
Sep 5, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yulong TanYuzhang Wu
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May 4, 2017·Immunological Reviews·Kun-Po LiDavid A Hildeman
Jun 3, 2021·International Journal of Molecular Sciences·Vittoria InfantinoVito Iacobazzi

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