Contraction of atrial smooth muscle reduces cardiac output in perfused turtle hearts

The Journal of Experimental Biology
William JoyceTobias Wang

Abstract

Unusual undulations in resting tension (tonus waves) were described in isolated atria from freshwater turtles more than a century ago. These tonus waves were soon after married with the histological demonstration of a rich layer of smooth muscle on the luminal side of the atrial wall. Research thereafter waned and the functional significance of this smooth muscle has remained obscure. Here, we provide evidence that contraction of the smooth muscle in the atria may be able to change cardiac output in turtle hearts. In in situ perfused hearts of the red-eared slider turtle (Trachemys scripta elegans), we demonstrated that activation of smooth muscle contraction with histamine (100 nmol kg-1 bolus injected into perfusate) reduced cardiac output by decreasing stroke volume (>50% decrease in both parameters). Conversely, inhibition of smooth muscle contraction with wortmannin (10 µmol l-1 perfusion) approximately doubled baseline stroke volume and cardiac output. We suggest that atrial smooth muscle provides a unique mechanism to control cardiac filling that could be involved in the regulation of stroke volume during diving.

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May 22, 2016·The Journal of Experimental Biology·William JoyceTobias Wang
May 25, 2016·Respiratory Physiology & Neurobiology·Christian Lind MalteTobias Wang
Nov 23, 2016·The Journal of Experimental Biology·William JoyceTobias Wang
Jul 12, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Nini SkovgaardTobias Wang
Oct 27, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·William JoyceTobias Wang
Mar 23, 2018·ELife·Bjarke JensenVincent M Christoffels
Apr 21, 2018·The Journal of Experimental Biology·Margo A LillieRobert E Shadwick
Jun 24, 2018·The Journal of Experimental Biology·Arnoldus Schytte Blix
Oct 24, 2018·The Journal of Experimental Biology·Daniel García-PárragaAndreas Fahlman

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Citations

Sep 12, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·William JoyceBjarke Jensen
Aug 5, 2020·The Journal of Experimental Biology·William Joyce, Tobias Wang
Feb 23, 2020·The Journal of Experimental Biology·William Joyce, Tobias Wang

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