Contraction-sensitive skeletal muscle afferents inhibit arterial baroreceptor signalling in the nucleus of the solitary tract: role of intrinsic GABA interneurons

Neuroscience
J T PottsS M Lee

Abstract

Arterial baroreceptor and skeletal muscle receptor afferents relay sensory information to the nucleus of the solitary tract (NTS) during exercise. Previous studies have suggested that skeletal muscle afferent input inhibits baroreflex function; however, detailed information on the role of muscle afferents and GABAergic mechanisms in the NTS is limited. Furthermore, identification of specific afferent modalities that activate GABAergic neurons in the NTS remains unknown. In the present study, we examined the neuroanatomical and physiological interactions between spinal dorsal horn cells that transmit contraction-sensitive input from skeletal muscle and GABAergic interneurons in the NTS. Biotinylated dextran amine (BDA, 10%, 25-100 nL) microinjection into dorsal horn of the cervical spinal cord was combined with glutamate decarboxylase (GAD) immunohistochemistry to visualize the nature of the relationship of BDA-labeled fibers in the NTS with GAD immunoreactivity (GAD-ir). BDA-labeled axons and terminal processes were localized in the medial, commissural, dorsomedial and dorsolateral subdivisions of the caudal NTS. Moreover, BDA-labeled fibers were observed in close proximity to GAD-ir structures throughout these regions of the N...Continue Reading

References

Jul 1, 1990·Journal of the Autonomic Nervous System·R ErmirioF R Calaresu
Mar 1, 1983·Circulation Research·S C Walgenbach, D E Donald
Mar 1, 1996·Journal of Neuroscience Methods·J F Paton
Apr 1, 1997·Brain Research. Brain Research Reviews·L B Wilson, G A Hand
Oct 18, 2000·Brain Research Bulletin·J T PottsJ F Paton
Mar 29, 2001·Autonomic Neuroscience : Basic & Clinical·P Boscan, J F Paton
Jul 30, 2002·Autonomic Neuroscience : Basic & Clinical·Jeffrey T PottsPetio I Anguelov

❮ Previous
Next ❯

Citations

Dec 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philip L JohnsonAnantha Shekhar
Dec 8, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Javier A Sala-MercadoDonal S O'Leary
May 20, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katherine A WilkinsonFrank L Powell
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chao-Yin ChenAnn C Bonham
May 13, 2014·BioMed Research International·Antonio C L NobregaAntonio Crisafulli
Nov 3, 2010·The Journal of Physiology·Han-Jun WangWei Wang
Sep 16, 2009·The Journal of Physiology·Michal G FortunaPatrice G Guyenet
Jul 2, 2010·Experimental Physiology·Jasenka Zubcevic, Jeffrey T Potts
Mar 9, 2004·The Journal of Physiology·Masashi IchinoseTakeshi Nishiyasu
Apr 19, 2005·Alcoholism, Clinical and Experimental Research·Guichu LiAbdel A Abdel-Rahman
Jul 5, 2005·The Journal of Physiology·Michael J Joyner
Jul 11, 2006·The Journal of Physiology·Angelina Y Fong, Jeffrey T Potts
Aug 19, 2006·The Journal of Physiology·Masashi IchinoseTakeshi Nishiyasu
Aug 18, 2012·Journal of Acupuncture and Meridian Studies·Min-Hee KimUk Namgung
Feb 28, 2006·Journal of Neuroscience Methods·Anthony E Pickering, Julian F R Paton
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·André L TeixeiraLauro C Vianna
Nov 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kenta YamamotoKenji Sunagawa
Sep 4, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pedro Boscan, Julian F R Paton
May 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Kenta YamamotoKenji Sunagawa
Sep 19, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephanie C Tjen-A-LooiJohn C Longhurst
Jan 31, 2020·Exercise and Sport Sciences Reviews·André L TeixeiraLauro C Vianna
Aug 2, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Alexandr M Degtyarenko, Marc P Kaufman
Apr 23, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cristiana A OgiharaMonica A Sato

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.