Contractions in the Isolated Uterus of a Rat Model of Polycystic Ovary Syndrome Compared to Controls in Adulthood

International Journal of Endocrinology and Metabolism
Maryam SajadiFahimeh Ramezani Tehrani

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women during the reproductive age. Considering disorders reported in women with PCOS, e.g. infertility, pregnancy complications (premature delivery, caesarean section and spontaneous miscarriages), and hormonal disorders, we hypothesized that uterine contractions in PCOS rats may be different from controls. We aimed to compare uterine contractions in PCOS rats with controls. Rats in the experimental group were subcutaneously injected with 5 mg of free testosterone on gestational day 20, while controls received solvent. The contractions of isolated uterus in offspring of both groups were recorded by the power lab system, after exposure to carbachol and oxytocin. Two-way analysis of variance was used to compare results between 2 groups. PCOS rats showed more irregular uterine contractions compared to controls. After exposure to carbachol, frequency, and resting tone in the PCOS rats were significantly increased compared to controls (P = 0.004, P = 0.02, respectively). After exposure to oxytocin, the frequency, resting tone and amplitude of rhythmic contractions did not differ between the 2 groups. Our study indicates irregular uterine contractions a...Continue Reading

References

Jun 22, 1979·Science·M S SoloffM J Fernstrom
Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·M Molnár, F Hertelendy
Aug 21, 1982·Lancet·D C WathesJ O Drife
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·V T Ang, J S Jenkins
Apr 1, 1983·Endocrinology·P A FieldsM J Fields
May 20, 1982·Nature·D C Wathes, R W Swann
Sep 28, 1995·The New England Journal of Medicine·S Franks
Sep 12, 1994·European Journal of Pharmacology·J N PennefatherF Mitchelson
Jul 1, 1994·The American Journal of Physiology·S E SzalK G Morgan
Jan 12, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·B K KimH Karaki
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
Mar 29, 2001·Physiological Reviews·G Gimpl, F Fahrenholz
Dec 1, 2001·Human Reproduction·C BullettiE Cincinelli
Mar 28, 2003·Brazilian Journal of Biology = Revista Brasleira De Biologia·F K MarcondesA P Tanno
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Mar 25, 2005·The New England Journal of Medicine·David A Ehrmann
Jun 27, 2006·Fertility and Sterility·Enrico Carmina, Ricardo Azziz
Jul 7, 2007·Seminars in Cell & Developmental Biology·Sam Mesiano, Toni N Welsh
Mar 1, 2012·The Journal of Pharmacology and Experimental Therapeutics·Emma S DariosStephanie W Watts
Oct 20, 2012·Acta Radiologica·Henrik LeonhardtMikael Hellström
Jun 27, 2013·Reproductive Biology and Endocrinology : RB&E·Jun Z QinHong Y Chen
Feb 18, 2014·Experimental Physiology·Fahimeh Ramezani TehraniFereidoun Azizi
Sep 16, 2015·Endocrine Journal·Mari SawadaYuji Hiramatsu
May 7, 2016·Reproductive Biomedicine Online·Kathrine Birch PetersenNina la Cour Freiesleben

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Citations

Aug 24, 2021·F&S Reviews·Pardis HosseinzadehChellakkan S Blesson

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