Contralateral functional reorganization of the speech supplementary motor area following neurosurgical tumor resection

Brain and Language
Srinivas ChivukulaSusan Y Bookheimer

Abstract

We evaluated plasticity in speech supplemental motor area (SMA) tissue in two patients using functional magnetic resonance imaging (fMRI), following resection of tumors in or associated with the dominant hemisphere speech SMA. Patient A underwent resection of a anaplastic astrocytoma NOS associated with the left speech SMA, experienced SMA syndrome related mutism postoperatively, but experienced full recovery 14 months later. FMRI performed 32 months after surgery demonstrated a migration of speech SMA to homologous contralateral hemispheric regional tissue. Patient B underwent resection of a oligodendroglioma NOS in the left speech SMA, and postoperatively experienced speech hesitancy, latency and poor fluency, which gradually resolved over 18 months. FMRI performed at 64 months after surgery showed a reorganization of speech SMA to the contralateral hemisphere. These data support the hypothesis of dynamic, time based plasticity in speech SMA tissue, and may represent a noninvasive neural marker for SMA syndrome recovery.

Citations

Sep 16, 2020·Current Neurology and Neuroscience Reports·Mar Jiménez de la PeñaManuel Recio Rodríguez
Nov 11, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Nardin SamuelMichael D Taylor
Jan 22, 2021·Neurosurgery·Saritha KrishnaShawn Hervey-Jumper
Dec 2, 2021·Stroke; a Journal of Cerebral Circulation·Xiaofeng DengJizong Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.