Contralateral neuropathic pain following a surgical model of unilateral nerve injury in rats

Regional Anesthesia and Pain Medicine
Maria Jose ArguisCarmen Gomar

Abstract

Damage to peripheral nerves provokes chronic neuropathic pain that lasts beyond the duration of the nerve injury. The presence of pain signs have been reported in areas other than those attributed to the injured nerve, i.e., in contralateral regions. We evaluated the presence, magnitude, and chronology of mechanical and cold allodynia in the contralateral paw of rats undergoing unilateral ligation of the L5 and L6 spinal nerves. Twenty-three male Sprague-Dawley rats underwent spinal nerve ligation of the left L5 and L6 spinal nerves (SNL group) and 7 rats received a sham surgery without nerve ligation (sham group). Signs of mechanical allodynia as assessed with von Frey filaments, and cold allodynia as assessed with the acetone drop test, were studied before surgery and throughout 21 postoperative days. Responses of ipsilateral and contralateral paws of the SNL group were compared between themselves and with those in the sham group. Rats in the SNL group developed mechanical and cold allodynia responses in the ipsilateral paw, and also in the contralateral paw. Allodynia in the contralateral paw appeared later, becoming statistically significant on day 10 after surgery for mechanical allodynia and on day 21 for cold allodynia a...Continue Reading

Citations

Jul 17, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Graham M PitcherJames L Henry
Sep 29, 2009·The Journal of Pain : Official Journal of the American Pain Society·Baptiste BessièreGuy Simonnet
Mar 27, 2012·NMR in Biomedicine·Kathleen E JacobsSandip Biswal
Apr 2, 2011·Neuropathology and Applied Neurobiology·D J ChewP J Shortland
Jul 26, 2015·Breast Cancer Research and Treatment·Dareen M AbdelazizSvetlana V Komarova
Jun 4, 2015·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Joanne F M Macaré van MaurikMoshe Kon
Mar 19, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Fuhai BaiLize Xiong

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