PMID: 11328699May 1, 2001Paper

Contralateral rotatory bias in the free-swimming test after unilateral hemispherectomy in adult Swiss mice

The International Journal of Neuroscience
T E KraheS L Schmidt

Abstract

In the free-swimming rotatory test mice spend most of the time swimming close to the wall of the container attempting to escape from an aversive test situation. The attraction to the wall may suggest that turning behavior in the free-swimming test reflects the existence of intrinsic sensory asymmetries, which determine preferential attention adhesion to one side. In order to test this hypothesis, we investigated the rotatory swimming behavior of mice submitted to a unilateral hemispherectomy at adulthood, a condition of extreme sensory asymmetry. Fifteen days after surgery procedures, each mouse was tested for 5 min on 3 different days. We found that the hemispherectomized mice had a significant strong bias to turn in the direction contralateral to their lesion. These data could be explained considering that, in attempting to escape from the test situation, animals bring the recipient wall into their intact sensory field and, as a consequence, set the direction of locomotion. Thus, the free-swimming test may be useful to investigate sensory asymmetries during an aversive test situation.

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Citations

Mar 1, 2012·Experimental Brain Research·Danielle Paes-BrancoCláudio C Filgueiras
Mar 16, 2011·Behavioural Brain Research·Anderson Ribeiro-CarvalhoYael Abreu-Villaça
Aug 25, 2004·Behavioural Brain Research·Cláudio C Filgueiras, Alex C Manhães
May 16, 2006·Behavioural Brain Research·Cláudio C FilgueirasAlex C Manhães
Jun 23, 2005·Behavioural Brain Research·Cláudio C Filgueiras, Alex C Manhães
Jun 29, 2016·Neuroscience and Biobehavioral Reviews·A K M Rezaul KarimLora T Likova
Sep 12, 2017·Somatosensory & Motor Research·Mattias De ConinckPeter Paul De Deyn

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