PMID: 12761994May 24, 2003Paper

Contralateral suppression of latency during distortion product otoacoustic emissions detection in guinea pigs

Zhonghua er bi yan hou ke za zhi
W KongW Zhang

Abstract

To investigate the cochlear micromechanics and the function of cochlear efferent system by detecting the distortion product otoacoustic emissions (DPOAE) with or without contralateral acoustic stimulation. The DPOAE amplitude and latency of the cubic DPOAE (2f1-f2) were measured at f2 = 2, 4 and 6 kHz with or without 70 dB SPL broad-band noise contralateral stimulation in ears of 12 healthy pigmented guinea pigs, which were divided into two groups(A and B) and tested with different primary intensity level combinations. On the next day, an operation was made to open the acoustic bulla of right ear in Group A. Kainic Acid (KA, 1 microL of 60 mmol/L) was applied onto the round window membrane and wiped up carefully after three hours. The amplitude and latency of the cubic DPOAE from the left ear were measured after 6 hours of KA administration, with or without contralateral noise stimulation. Before the KA treatment, the amplitude of DPOAE induced by primaries of equal levels (L1 = L2) presented no significant change and the latency prolonged significantly during contralateral acoustic stimulation (Group A). But the amplitude at 2, 4 kHz of DPOAE induced by primaries of different levels (L1 > L2) decreased significantly and the la...Continue Reading

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