Contrast between cardiac left ventricle and diaphragm muscle in expression of genes involved in carbohydrate and lipid metabolism

Respiratory Physiology & Neurobiology
Erik van LunterenMichelle Moyer

Abstract

The heart and diaphragm both need appropriate metabolic machinery to ensure long-term energy supplies, as they must contract rhythmically without cessation for the entire lifetime of the organism to ensure homeostasis of oxygen and carbon dioxide exchange. However, their energy requirements differ due to disparities in mechanical loads. Understanding how these two muscles converge and diverge in their approaches to meeting their metabolic demands may suggest novel strategies for improving cardiac and skeletal muscle long-term performance in health and disease. To assess this at a transcriptional level, expression of genes involved in carbohydrate and lipid metabolism was assessed using microarrays in rats. There were 594 genes with >2-fold differential expression between left ventricle of the heart and diaphragm; 307 were expressed heart>diaphragm and 287 diaphragm>heart. Assignment to gene ontology groups revealed over-representation for "carbohydrate metabolism" (P=0.005, n=32 genes or 5.4% of all genes with differential expression) and "lipid metabolism" (P=0.0012, n=48 genes or 8.1% of all genes with differential expression). For carbohydrate there were 14 genes with heart>diaphragm and 18 genes with diaphragm>heart, and fo...Continue Reading

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Dec 23, 2006·Respiratory Physiology & Neurobiology·Erik van Lunteren, Patrick Leahy
Jun 15, 2007·American Journal of Physiology. Endocrinology and Metabolism·Erik van Lunteren, Michelle Moyer

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Citations

Jan 16, 2014·BMC Endocrine Disorders·Erik van LunterenSarah Spiegler
Nov 17, 2009·PloS One·Erik van Lunteren, Michelle Moyer
Nov 10, 2013·BMC Endocrine Disorders·Erik van Lunteren, Michelle Moyer

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