Contrast bolus optimization for cardiac 16-slice computed tomography: comparison of contrast medium formulations containing 300 and 400 milligrams of iodine per milliliter

Investigative Radiology
Carsten RistChristoph R Becker

Abstract

The aims of our study were to compare contrast injection protocols with contrast media containing 300 and 400 mg iodine per milliliter for optimal contrast enhancement in cardiac multidector row computed tomography (CT) and to evaluate the correlation of test bolus curve parameters with the final contrast density of the main bolus. Sixty patients with known or suspected coronary artery disease were included in a prospective double-blind study. Patients were randomized to 2 groups. Group 1 received 83 mL of a contrast medium (CM) containing 300 mg of iodine (Iomeron 300, Bracco Imaging SpA, Milan, Italy) at a flow rate of 3.3 mL/s, whereas group 2 received 63 mL of the same agent containing 400 mg of iodine (Iomeron 400) at a flow rate of 2.5 mL/s. The test bolus volumes were 20 mL and 15 mL, respectively. Imaging was performed using a 16-slice CT system (16DCT; Somatom Sensation 16, Siemens Medical Solutions, Forchheim, Germany). Contrast densities (Hounsfield Units [HU]) were determined in the cardiac chambers and in the main coronary arteries. The peak density and area under the curve of the test bolus were calculated for each patient. The mean contrast densities of the coronary arteries were 259.1 +/- 46.7 HU for group 1 and...Continue Reading

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Citations

Jun 4, 2008·Cardiovascular and Interventional Radiology·Florian F BehrendtGeorg Mühlenbruch
Oct 16, 2007·European Radiology·Filippo CademartiriGabriel P Krestin
Jul 25, 2008·European Radiology·Georg MühlenbruchAndreas H Mahnken
Aug 21, 2013·European Radiology·Alexander LembckeAlexander Huppertz
Nov 13, 2012·Journal of Digital Imaging·Tracy J RobinsonLee M Mitsumori
Feb 22, 2008·AJR. American Journal of Roentgenology·Kyongtae T BaePamela K Woodard
Jun 20, 2008·AJR. American Journal of Roentgenology·Florian F BehrendtGeorg Mühlenbruch
Apr 22, 2009·AJR. American Journal of Roentgenology·Pamela T JohnsonElliot K Fishman
Apr 27, 2013·AJR. American Journal of Roentgenology·Florian F BehrendtAndreas H Mahnken
May 3, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Eun-Ah ParkSang-Il Choi
Apr 7, 2007·Journal of Computer Assisted Tomography·Uma D NumburiSandra S Halliburton
Nov 7, 2007·Investigative Radiology·Thorsten R C JohnsonChristoph R Becker
Apr 1, 2008·European Radiology·Carsten RistKonstantin Nikolaou
May 24, 2012·The International Journal of Cardiovascular Imaging·Wen Jie YangFu Hua Yan
Apr 20, 2011·Journal of Medical Imaging and Radiation Oncology·Florian F BehrendtAndreas H Mahnken

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