Contrast coating for the surface of flat polyps at CT colonography: a marker for detection

European Radiology
David H KimPerry J Pickhardt

Abstract

To assess the frequency of oral contrast coating of flat polyps, which may promote detection, and influencing factors within a screening CT colonography (CTC) population. This was a retrospective, observational study performed at one institution. From 7,426 individuals, 123 patients with 160 flat polyps were extracted. Flat polyps were defined as plaque-like, raised at most 3 mm in height and reviewed for contrast coating. Factors including demographic variables such as age and sex, and polyp variables such as polyp size, location and histology were analysed for effect on coating. Of 160 flat polyps (mean size 9.4 mm ± 3.6), 78.8 % demonstrated coating. Mean coat thickness was 1.5 mm ± 0.6; 23.8 % (n = 30) demonstrated a thin film of contrast. Large size (≥10 mm) and proximal colonic location (relative to splenic flexure) were predictive variables by univariate logistic regression [OR (odds ratio) 3.4 (CI 1.3-8.9; p = 0.011), 2.0 (CI 1.2-3.5; p = 0.011), respectively]. Adenomas (OR 0.37, CI 0.14-1.02; p = 0.054) and mucosal polyps or venous blebs (OR 0.07, CI 0.02-0.25; p < 0.001) were less likely to coat than serrated/hyperplastic lesions. Age and sex were not predictive for coating (p = 0.417, p = 0.499, respectively). Surfac...Continue Reading

References

Dec 28, 2002·The American Journal of Surgical Pathology·Emina TorlakovicJahn M Nesland
Dec 6, 2003·The New England Journal of Medicine·Perry J PickhardtWilliam R Schindler
Oct 27, 2004·AJR. American Journal of Roentgenology·Perry J PickhardtWilliam R Schindler
Dec 21, 2005·Journal of Computer Assisted Tomography·Stacy D O'ConnorPerry J Pickhardt
May 23, 2006·AJR. American Journal of Roentgenology·Seong Ho ParkYoung Il Min
Jul 25, 2007·AJR. American Journal of Roentgenology·Perry J Pickhardt
Nov 13, 2007·Gastroenterology Clinics of North America·Michael J O'Brien
Mar 6, 2008·JAMA : the Journal of the American Medical Association·Roy M SoetiknoShai Friedland
Dec 17, 2008·Annals of Internal Medicine·Nancy N BaxterLinda Rabeneck
Mar 17, 2010·Academic Radiology·Perry J PickhardtJessica B Robbins
Dec 25, 2010·Abdominal Imaging·Christopher M BuchachPerry J Pickhardt
Apr 15, 2011·The American Journal of Surgical Pathology·Joanna A GibsonRobert D Odze
Jan 3, 2012·European Radiology·David H KimPerry J Pickhardt
Sep 13, 2012·World Journal of Gastroenterology : WJG·Shinya IshigookaFumio Itoh
Dec 5, 2012·Journal of Gastroenterology·Christophe RostyVicki L J Whitehall

Citations

Jun 28, 2016·Seminars in Ultrasound, CT, and MR·Lorna Woodbridge, Peter Wylie
Oct 28, 2015·BioMed Research International·Justin L SovichSubhasis Misra
Dec 17, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L Bonelli
Apr 14, 2016·Abdominal Radiology·C Daniel Johnson
Dec 11, 2014·Digestive Diseases and Sciences·Perry J Pickhardt
Nov 14, 2014·Current Opinion in Gastroenterology·Perry J Pickhardt
Feb 7, 2018·Abdominal Radiology·Seong Ho Park, David H Kim
Feb 17, 2018·Abdominal Radiology·Kevin J Chang, David H Kim
Jun 22, 2018·The British Journal of Radiology·Anu E ObaroAndrew A Plumb
Jul 31, 2018·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Meghan G LubnerKhaled M Elsayes
Mar 30, 2016·The American Journal of Gastroenterology·J E G IJspeertJ Stoker
Feb 28, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Andrew A PlumbA Thrower
Nov 13, 2019·AJR. American Journal of Roentgenology·Jeannine A RubyPerry J Pickhardt
Jan 9, 2020·AJR. American Journal of Roentgenology·Perry J Pickhardt
Jul 29, 2017·AJR. American Journal of Roentgenology·Timothy J ZiemlewiczPerry J Pickhardt
Aug 22, 2019·Abdominal Radiology·Lori Mankowski GettlePerry J Pickhardt
Nov 18, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·David H KimPerry J Pickhardt
Feb 18, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Michael SchonbergerAbraham H Dachman
Mar 15, 2020·Insights Into Imaging·Thomas MangPhilippe A Lefere
Apr 16, 2021·Seminars in Roentgenology·Zina J RicciJudy Yee

Related Concepts

Adenoma, Trabecular
Micropaque Oral
Malignant Tumor of Colon
Colonic Polyps
Radiographic contrast media
Verografin
Retrospective Studies
Statistical Sensitivity
Computed Tomographic Colonography
Adenoma

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