Contrast-enhanced color Doppler sonography of uveal melanomas

Journal of Clinical Ultrasound : JCU
A J LemkeR Felix

Abstract

The purpose of our study was to evaluate the use of the galactose microbubble-based contrast agent Levovist in color Doppler sonography of uveal melanomas. We also evaluated the use of the resistance index and pulsatility index in differentiating tumor-associated vessels from normal vessels in patients with uveal melanomas. In this prospective study, 40 patients with uveal melanoma were examined with color Doppler sonography before and after the administration of the contrast agent Levovist. The Doppler signals were recorded from both the tumor and the orbit and were evaluated quantitatively and qualitatively. Tumor-associated vessels were detected without contrast enhancement in 36 of 40 patients and with contrast enhancement in 38 of 40 patients. The spectral characteristics of the Doppler signals did not change after the injection of Levovist. There were no differences-qualitative or quantitative-in Doppler signals between normal and tumor-associated vessels. The injection of Levovist slightly improved the detection of small vessels in uveal melanomas and the orbit but did not help to differentiate between normal vessels and tumoral vessels. The differentiation of a solid tumor from subretinal hemorrhage or effusion was impr...Continue Reading

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Citations

Jan 27, 2005·AJR. American Journal of Roentgenology·Klaus SchlottmannJürgen Schölmerich
Aug 27, 2003·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Viktor SzatmáriKároly Vörös
Jan 5, 2002·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·S S HanY J Lee
Mar 10, 2018·Veterinary Ophthalmology·Sunghwa HongJihye Choi
Sep 28, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Frederic L Lizzi, D Jackson Coleman
Jan 21, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Yao ZhangWenwei Chen

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