Contrast-enhanced harmonic endoscopic ultrasound using time-intensity curve analysis predicts pathological grade of pancreatic neuroendocrine neoplasm

Journal of Medical Ultrasonics
Saimon TakadaHiroyuki Okada

Abstract

Histological grading is important for the treatment algorithm in pancreatic neuroendocrine neoplasms (PNEN). The present study examined the efficacy of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) and time-intensity curve (TIC) analysis of PNEN diagnosis and grading. TIC analysis was performed in 30 patients using data obtained from CH-EUS, and a histopathological diagnosis was made via EUS-guided fine-needle aspiration or surgical resection. The TIC parameters were analyzed by dividing them into G1/G2 and G3/NEC groups. Then, patients were classified into non-aggressive and aggressive groups and evaluated. Twenty-six patients were classified as G1/G2, and four as G3/NEC. From the TIC analysis, five parameters were obtained (I: echo intensity change, II: time for peak enhancement, III: speed of contrast, IV: decrease rate for enhancement, and V: enhancement ratio for node/pancreatic parenchyma). Three of these parameters (I, IV, and V) showed high diagnostic performance. Using the cutoff value obtained from the receiver-operating characteristic (ROC) analysis, the correct diagnostic rates of parameters I, IV, and V were 96.7%, 100%, and 100%, respectively, between G1/G2 and G3/NEC. A total of 21 patients were class...Continue Reading

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Citations

Oct 7, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Rei IshikawaMasatoshi Kudo
Jan 1, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Eizaburo Ohno
Mar 4, 2021·Ultrasound in Medicine & Biology·Masayuki KitanoUNKNOWN Working group for the International Consensus Guidelines for Contrast-Enhanced Harmonic Endoscopic Ultrasound
Jul 3, 2021·Journal of Clinical Medicine·Giuseppinella MelitaGianlorenzo Dionigi

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