PMID: 11912114Mar 26, 2002Paper

Contrast-enhanced MRI in acute optic neuritis: relationship to visual performance

Brain : a Journal of Neurology
Mark J KupersmithDaniel Lefton

Abstract

The location and extent of an abnormal signal on MRI of the optic nerve affected by optic neuritis are said to correlate with the severity of initial visual loss and recovery. We used gadolinium-enhanced fat-suppressed MRI to show abnormal enhancement of the optic nerve to determine the sensitivity of this modality in acute optic neuritis and whether the abnormal enhancement correlates with presenting visual deficits or recovery. A total of 107 patients, 93 with follow-up (68 steroid treated), were included; 101 patients had enhancement of the affected optic nerve and no unaffected nerve enhanced. The baseline visual performance was similar between nerves with and without enhancement. Optic nerves with enhancement in the optic canal had poorer colour vision (P = 0.04) and nerves with all segments involved had worse threshold perimetry (P = 0.001) and colour vision (P = 0.008). Nerves with enhancement >10 mm had worse threshold perimetry (P = 0.004), while nerves with enhancing segments >17 mm had poorer baseline visual acuity (P = 0.02), threshold perimetry (P = 0.009) and colour vision (P = 0.01). For all parameters of vision, recovery was similar regardless of location or length of abnormal enhancement. Abnormal contrast enha...Continue Reading

References

Mar 11, 1991·Journal of Neurosurgery·J GuyJ Schiffman
Mar 1, 1991·Journal of Computer Assisted Tomography·R D TienJ Szumowski
Apr 1, 1991·Brain : a Journal of Neurology·W A StewartD W Paty
Jun 1, 1991·Brain : a Journal of Neurology·D BarnesW I McDonald
Oct 1, 1990·AJR. American Journal of Roentgenology·L E HendrixL F Czervionke
Feb 1, 1988·Neurology·D H MillerW I McDonald
Oct 27, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T IwasawaA Nozaki

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Citations

Jan 6, 2005·Neuroradiology·S J HickmanD H Miller
Mar 3, 2007·Neuroradiology·A Rovira CañellasX Montalban Gairin
Jan 29, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kristin M GalettaLaura J Balcer
Jun 7, 2012·Acta neurologica Belgica·Basak Karakurum GokselMehmet Karatas
Aug 15, 2003·Ophthalmology·Hilary E FazzoneMark J Kupersmith
Apr 30, 2011·Eye·D PauA G Lee
Dec 2, 2008·Nature Clinical Practice. Neurology·Elliot M FrohmanLaura J Balcer
Jun 23, 2010·Brain : a Journal of Neurology·Andrew P D HendersonDavid H Miller
Jun 5, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Sangeeta KhannaGregory P Van Stavern
Jun 10, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J SellnerB Hemmer
Oct 17, 2002·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michael O RussAndreas Kleinschmidt
Apr 20, 2006·The British Journal of Ophthalmology·J de la Cruz, M J Kupersmith
Aug 2, 2012·Radiology Research and Practice·Giulia MascioliGabriele Polonara
Jul 1, 2005·Neurosurgery·Luis M TumialánNancy J Newman
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Rohit BakshiJerry S Wolinsky
Aug 16, 2014·Journal of the Neurological Sciences·John H PulaJennifer Daily
Sep 14, 2014·Seminars in Ultrasound, CT, and MR·David James Swienton, Adam G Thomas
Jul 9, 2014·Nature Reviews. Neurology·Axel PetzoldGordon T Plant
Dec 19, 2009·AJNR. American Journal of Neuroradiology·K-O LövbladM Filippi
Sep 19, 2012·Nature Reviews. Neurology·Valentina TomassiniJacqueline Palace
Oct 28, 2015·Postgraduate Medical Journal·R SawayaR Hamam
Apr 24, 2013·Neuroimaging Clinics of North America·Naila MakhaniManohar Shroff
Mar 9, 2012·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Zareen FatimaTsutomu Araki
May 18, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Erik V BurtonElliot M Frohman
Jan 20, 2010·Survey of Ophthalmology·Monika PradhanMichael Vaphiades
Dec 10, 2008·Neuroimaging Clinics of North America·Christopher C Glisson, Steven L Galetta
Feb 6, 2008·Emergency Medicine Clinics of North America·Michael Vortmann, Jeffrey I Schneider
Nov 7, 2006·La Presse médicale·Caroline Papeix
Jan 15, 2008·Survey of Ophthalmology·Molly E Gilbert, Michael Vaphiades
Apr 27, 2005·Annals of Neurology·Ahmed T ToosyAlan J Thompson
Jul 20, 2005·Journal of Magnetic Resonance Imaging : JMRI·Elena VinogradovRobert E Lenkinski
Apr 12, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Simon J Hickman
Sep 30, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ha-Kyu JeongSeth A Smith
Feb 27, 2010·Annals of Neurology·Thomas M JenkinsAlan J Thompson
Oct 10, 2006·Journal of the Neurological Sciences·Michael J ProMark J Kupersmith
Jun 15, 2005·American Journal of Ophthalmology·Anthony C Arnold
Feb 3, 2016·Annals of Neurology·Mariko HokariIzumi Kawachi
Dec 18, 2013·Lancet Neurology·Ahmed T ToosyDavid H Miller
May 15, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Concepción GonzálezGuillermo Izquierdo
Oct 5, 2016·Heliyon·Neil K BansalSohil H Patel
Oct 12, 2016·Journal of Neuroimmunology·Tetsuya AkaishiKazuo Fujihara
Oct 16, 2016·Continuum : Lifelong Learning in Neurology·Gabriella Szatmáry

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