Contrast-enhanced sonography for the characterisation of hepatocellular carcinomas--correlation with histological differentiation

Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie
D StrobelT Bernatik

Abstract

We aimed to characterise the vascularisation patterns of hepatocellular carcinomas in contrast-enhanced sonography in correlation to the histological differentiation of hepatocellular carcinomas (HCC), and we also compared the diagnostic value of contrast-enhanced sonography in addition to B-scan sonography and power Doppler sonography. 51 hepatocellular carcinomas (21 well differentiated, 27 moderately differentiated, 3 poorly differentiated) were examined: by B-scan sonography, power Doppler sonography and contrast-enhanced sonography using phase or pulse inversion harmonic imaging with a low mechanical index (< 0.3) and second generation microbubble contrast medium (Optison, Sonovue) as echo-enhancing agent. Lesion vascularity and the kinetics of contrast enhancement within the lesions in the early arterial phase, arterial phase, portal phase and late phase were analysed. The final diagnosis of a HCC was assessed after B-scan sonography, power Doppler sonography and contrast-enhanced sonography. Hypervascularisation and/or irregular tumour vascularisation could be detected in 18/48 HCCs (37.5%) by power Doppler sonography. After contrast application, 46/51 HCCs (90.2%) were identified as hyperechoic lesions during the early ...Continue Reading

Citations

Apr 14, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M HünerbeinP M Schlag
Apr 12, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·G Arlt, E Fuhrmann
Mar 5, 2008·Abdominal Imaging·Tommaso Vincenzo BartolottaRoberto Lagalla
Apr 4, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Okka W HamerStefan Feuerbach
Feb 22, 2008·AJR. American Journal of Roentgenology·Linda ChamiDominique Elias
Nov 28, 2012·European Radiology·Michele Di MartinoCarlo Catalano
Dec 6, 2014·Future Oncology·Luigi Bolondi
Jan 12, 2007·Der Internist·Bita BoozariMichael Gebel
Mar 8, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Bita BoozariMichael Gebel
Mar 31, 2010·Ultrasound in Medicine & Biology·Fabio PiscagliaLuigi Bolondi
Dec 7, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M PompiliG L Rapaccini
Jul 10, 2007·Ultrasound in Medicine & Biology·R KonopkeS Kersting
Jun 12, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ahmed AlzaraaDavid Lloyd
Oct 1, 2009·Journal of Clinical Ultrasound : JCU·Alexandra von HerbayMichael Gregor
Oct 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M Rasool AljabiriAndrew K Burroughs
May 31, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Suping GuoCheng Zhang
May 29, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Zhili WangJianhong Xu

Related Concepts

Cell Differentiation Process
Radiographic contrast media
Liver Carcinoma
Malignant Neoplasm of Liver

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.